Association of single nucleotide polymorphism of hTERT candidate genes with gastric carcinoma

万顺梅; 房殿春; 杨仕明; 汪荣泉; 彭贵勇; 陈文生

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Association of single nucleotide polymorphism of hTERT candidate genes with gastric carcinoma

更新时间：2026-01-09

- Association of single nucleotide polymorphism of hTERT candidate genes with gastric carcinoma
- Journal of Army Medical University Vol. 30, Issue 7, Pages: 603-605(2008)
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  CLC： R345;R394.3;R735.2
- Published：2008
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万顺梅,房殿春,杨仕明,汪荣泉,彭贵勇,陈文生.人端粒酶催化亚单位基因单核苷酸多态性与胃癌的关系[J].陆军军医大学学报(原第三军医大学学报),2008,30(07):603-605.

　WAN Shun-mei,FANG Dian-chun,YANG Shi-ming,WANG Rong-quan,PENG Gui-yong,CHEN Wen-sheng.Association of single nucleotide polymorphism of hTERT candidate genes with gastric carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(07):603-605.
万顺梅,房殿春,杨仕明,汪荣泉,彭贵勇,陈文生.人端粒酶催化亚单位基因单核苷酸多态性与胃癌的关系[J].陆军军医大学学报(原第三军医大学学报),2008,30(07):603-605. DOI：

　WAN Shun-mei,FANG Dian-chun,YANG Shi-ming,WANG Rong-quan,PENG Gui-yong,CHEN Wen-sheng.Association of single nucleotide polymorphism of hTERT candidate genes with gastric carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(07):603-605. DOI：

摘要

目的探讨人端粒酶催化亚单位基因(human telomerase catalytic subunit，hTERT) Ex2-659A/G位点单核苷酸多态性与胃癌患者发病风险的关系。方法对甘肃西部三家医院外科手术切除168例胃癌患者（病例组）和同期在上述医院查体的健康人群156例（对照组）进行病例对照研究；采用聚合酶链反应和限制性片段长度多态性技术(PCRpRFLP)对2组进行基因型分析，比较各基因型分布频率和发病风险的关系。结果病例组hTERT Ex2-659A/G位点AA、AG、GG基因型的频率与对照组相比无显著差异。病例组A、G等位基因频率分别为44.74%和55.26%

对照组为43.42%和56.58%

2组A、G等位基因型频率比较有显著性差异(χ

=5.373 4，P=0.020 4)。与G/G基因型相比，A/G和A/A 2种基因型的个体患胃癌的危险度（OR）分别为0.519 (95% CI:0.310～0.870，P=0.013)、0.550(95% CI:0.255～1.188，P=0.128)。结论 hTERT Ex2-659A/G单核苷酸多态性可能为胃癌的保护因素。

Abstract

Objective To explore the association of single nucleotide polymorphism (SNP) of Ex2-659A/G of human telomerase catalytic subunit (hTERT) with the incidence of gastric carcinoma. Methods Totally 168 patients of gastric carcinoma and 156 cancer-free controls were genotyped by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (PCR-RFLP). Result The frequency of AA

GG genotypes of hTERT Ex2-659A/G was 10.63%

47.5%

and 41.88% in gastric carcinoma patients and 15.13%

56.58% and 28.29% in controls

respectively. The OR for AG and AA genotypes was 0.519 (95% CI: 0.310-0.870

P=0.013)

0.550 (95% CI: 0.255-1.188

P=0.128) in comparison with GG genotype

respectively. There was significant difference in genotype distribution and allele frequency of Ex2659A/G polymorphism (χ2=5.373 4

P=0.020 4) between the 2 groups. Conclusion Our results indicate that Ex2-659A/G SNP of hTERT gene may be associated with reduced risk for gastric carcinoma.

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