Methods on enhancing success rate and survival rate of rat model of myocardial infarction

向平; 宋银子; 陈沅; 涂柳; 朱高慧

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Methods on enhancing success rate and survival rate of rat model of myocardial infarction

更新时间：2026-01-09

- Methods on enhancing success rate and survival rate of rat model of myocardial infarction
- Journal of Army Medical University Vol. 30, Issue 4, Pages: 329-332(2008)
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  CLC： R-332;R542.22;R971.2
- Published：2008
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向平,宋银子,陈沅,涂柳,朱高慧.提高大鼠心肌梗死模型成功率及存活率的研究[J].陆军军医大学学报(原第三军医大学学报),2008,30(04):329-332.

　XIANG Ping,SONG Yin-zi,CHEN Yuan,TU Liu,ZHU Gao-hui.Methods on enhancing success rate and survival rate of rat model of myocardial infarction[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(04):329-332.
向平,宋银子,陈沅,涂柳,朱高慧.提高大鼠心肌梗死模型成功率及存活率的研究[J].陆军军医大学学报(原第三军医大学学报),2008,30(04):329-332. DOI：

　XIANG Ping,SONG Yin-zi,CHEN Yuan,TU Liu,ZHU Gao-hui.Methods on enhancing success rate and survival rate of rat model of myocardial infarction[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(04):329-332. DOI：

摘要

目的探讨结扎位置、冠状静脉变异等因素对大鼠心肌梗死（myocardial infarction， MI）模型建立的成功率以及利多卡因的使用对模型的死亡率的影响。方法 120只雄性SD大鼠按随机排列表法分为4组：低位结扎且冠状静脉不明显组（30只）、低位结扎且冠状静脉明显组（30只）、高位结扎组（30只）以及高位结扎且使用利多卡因组（30只），计算建模后各组死亡率，测定各组心功能及梗死面积。结果结扎位置较高时模型成功率为93.0%

而结扎位置较低时的成功率为67.3％；高位结扎不加利多卡因大鼠死亡率为43.3%，加用利多卡因后大鼠死亡率则降为13.3%。结论高位结扎时能明显提高模型成功率，加用利多卡因后死亡率明显下降。

Abstract

Objective To investigate the effects of different ligation position

vena coronaria variation and lidocaine on myocardial infarction size and mortality in rats. Methods Totally 120 male SD rats were divided into four groups with 30 rats in each group: low ligation with invisible vena coronaria

low ligation with visible vena coronaria

high ligation

and high ligation plus lidocaine. Results MI was successfully created in 93.0% rats of high ligation groups and in 67.3% rats of low ligation groups. The mortality was 43.3% in rats of high ligation groups

only 13.3% in rats when lidocaine in use. Conclusion High ligation increases the success rate of rat model of myocardial infarction and the application of lidocaine decreases the mortality of the rat model.

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