Interleukin 24 suppresses the growth of malignant glioma cells in vitro and in vivo

王跃红; 赵文清; 李文玲; 潘宝根; 梁传栋; 赵晓云

您当前的位置：

首页 >

文章列表页 >

Interleukin 24 suppresses the growth of malignant glioma cells in vitro and in vivo

更新时间：2026-01-09

- Interleukin 24 suppresses the growth of malignant glioma cells in vitro and in vivo
- Journal of Army Medical University Vol. 30, Issue 3, Pages: 229-232(2008)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R73-362;R730.264;R979.19
- Published：2008
- 稿件说明：
移动端阅览
王跃红,赵文清,李文玲,潘宝根,梁传栋,赵晓云.白介素-24抑制胶质瘤细胞生长的体内外实验研究[J].陆军军医大学学报(原第三军医大学学报),2008,30(03):229-232.

　WANG Yue-hong,ZHAO Wen-qing,LI Wen-ling,PAN Bao-gen,LIANG Chuan-dong,ZHAO Xiao-yun.Interleukin 24 suppresses the growth of malignant glioma cells in vitro and in vivo[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(03):229-232.
王跃红,赵文清,李文玲,潘宝根,梁传栋,赵晓云.白介素-24抑制胶质瘤细胞生长的体内外实验研究[J].陆军军医大学学报(原第三军医大学学报),2008,30(03):229-232. DOI：

　WANG Yue-hong,ZHAO Wen-qing,LI Wen-ling,PAN Bao-gen,LIANG Chuan-dong,ZHAO Xiao-yun.Interleukin 24 suppresses the growth of malignant glioma cells in vitro and in vivo[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(03):229-232. DOI：

摘要

目的探讨白介素-24基因转染对胶质瘤生长的影响。方法将载有人白介素-24 cDNA的新型重组腺病毒(Ad5F35-IL24)感染人胶质瘤细胞系U251，体外观察Ad5F35IL24对该细胞系生长的影响；建立人胶质瘤动物模型，瘤内注射Ad5F35-IL24，观察肿瘤生长情况；用流式细胞仪检测其凋亡和Bax/Bcl-2的表达情况。结果 Ad5F35-IL24感染U251细胞和肿瘤组织后，IL-24蛋白高表达，U251细胞和组织的生长受到明显抑制，其凋亡率明显升高，Bax/Bcl-2也明显升高。结论白介素-24具有抑制人胶质瘤细胞系U251生长和诱导凋亡作用。Ad5F35-IL24转导白介素-24基因可能是一种有效的胶质瘤基因治疗途径。

Abstract

Objective To explore the potential use and the effect of adenovirus-mediated interleukin 24 gene (Ad5F35-IL24) therapy for malignant glioma. Methods After Ad5F35-IL24 was transfected into human malignant glioma cell line U251

we observed the growth of U251 cells. Ad5F35-IL24 was injected into tumor nodules of BALB/c mouse models of human glioma

and the tumor growth was observed. The apoptosis of tumor cells and their Bax/Bcl-2 expressions were detected with flow cytometer. Results The expression of IL-24 proteins were expressed highly after transfection of Ad5F35-IL24. The growth of U251 cells and xenograft tumors was suppressed obviously

and their apoptosis and Bax/Bcl-2 expression were significantly elevated. Conclusion IL-24 induces growth suppression and apoptosis in human glioma cells U251. Adenovirus-mediated IL-24 gene therapy is a potential effective approach in the treatment of malignant glioma.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Value of MRI radiomics based on intratumoral and peritumoral heterogeneity in predicting spatial patterns of locally recurrent high-grade gliomas

Hypoxic transcriptional phenotype and cellular ultrastructural changes of tumor-associated macrophages in gliomas

Value of ambulatory electroencephalogram in evaluation of postoperative withdrawal of antiepileptic drugs in patients with glioma-related epilepsy

Application of different post-processing modes of dynamic contrast enhanced magnetic resonance imaging in glioma grading

Rab18 is a potential molecular biomarker for diagnosis and assessing the progression of human gliomas

Related Author

WANG Hanwei

ZENG Linlan

ZHAO Mimi

LI Xuan

XIE Huan

LI Xiaoguang

YI Liang

WU Yi

Related Institution

Department of Digital Medicine, Faculty of Biomedical Engineering and Imaging Medicine， Army Medical University （Third Military Medical University）

Department of Radiology， Chongqing Clinical Research Centre of Imaging and Nuclear Medicine, Faculty of Biomedical Engineering and Imaging Medicine， Army Medical University （Third Military Medical University）

Department of Neurosurgery， Army Medical Center of PLA/Daping Hospital of Third Military Medical University， Chongqing, Faculty of Biomedical Engineering and Imaging Medicine， Army Medical University （Third Military Medical University）

School of Medicine， Chongqing University

Institute of Pathology

⁰