Relationship between ATP-binding transporter A1 gene variation and plasma high density lipoprotein cholesterol level

李亚; 王玉明; 贺勇; 潘克俭

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Relationship between ATP-binding transporter A1 gene variation and plasma high density lipoprotein cholesterol level

更新时间：2026-01-09

- Relationship between ATP-binding transporter A1 gene variation and plasma high density lipoprotein cholesterol level
- Journal of Army Medical University Vol. 29, Issue 24, Pages: 2347-2349(2007)
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  CLC： R181.33;R344.81;R446.69
- Published：2007
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李亚,王玉明,贺勇,潘克俭.ABCA1基因变异与血浆高密度脂蛋白胆固醇水平的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(24):2347-2349.

　LI Ya,WANG Yu-ming,HE Yong,PAN Ke-jian.Relationship between ATP-binding transporter A1 gene variation and plasma high density lipoprotein cholesterol level[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(24):2347-2349.
李亚,王玉明,贺勇,潘克俭.ABCA1基因变异与血浆高密度脂蛋白胆固醇水平的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(24):2347-2349. DOI：

　LI Ya,WANG Yu-ming,HE Yong,PAN Ke-jian.Relationship between ATP-binding transporter A1 gene variation and plasma high density lipoprotein cholesterol level[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(24):2347-2349. DOI：

摘要

目的探讨腺苷三磷酸结合盒转运体A1（ATP-binding transporter A1， ABCA1）基因多态性与汉族人群血浆高密度脂蛋白胆固醇（high-density lipoprotein cholesterol， HDL-C）水平的关系。方法采用聚合酶链反应限制性片段长度多态性分析技术检测376例无血缘关系的正常汉族人ABCA1基因M883I、R1587K和R219K多态性。结果研究人群中KK1587基因型者HDL-C水平明显低于RR1587和RK1587基因型者（P0.05）。按性别分层后，仅女性KK1587基因型者HDL-C水平低于RR1587和RK1587基因型者（P0.01）。一般线性模型分析显示，R1587K多态对女性个体HDL-C水平变异的贡献度为2.3%（P0.01）。结论 ABCA1基因M883I和R219K多态与汉族人群HDL-C水平无关，但K1587等位基因以隐性作用方式与女性HDL-C水平降低有关。

Abstract

Objective To investigate the association between the ATP-binding cassette transporter A1 (ABCA1) gene polymorphisms and plasma high density lipoprotein cholesterol (HDL-C) level in Chinese general population. Methods M883I

R1587K and R219K polymorphisms of the ABCA1 gene were detected by polymerase chain reactionrestriction fragment length polymorphism technique in 376 unrelated Chinese healthy subjects. Results In the study population

the subjects with the KK1587 genotype had markedly lower HDL-C levels than those with RR1587 and RK1587 genotypes (P0.05). When subgroups were divided by gender

the KK1587 genotype was associated with lower HDL-C levels compared with the RR1587 and RK1587 genotypes only in women (P0.01). Moreover

the general linear model showed that R1587K polymorphism led to 2.3% of the variation in HDL-C levels in women studied (P0.01). Conclusion M883I and R219K polymorphisms of the ABCA1 gene are not correlated with HDL-C level in Chinese population

but the recessive K1587 allele may be involved in the decreased level of HDL-C in women.

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