Effects of simulated toss on myocardial mechanics following early burn injury in rabbits

王广; 黄跃生; 罗中华; 阮兢; 张兵钱; 肖荣; 雷泽源

您当前的位置：

首页 >

文章列表页 >

Effects of simulated toss on myocardial mechanics following early burn injury in rabbits

更新时间：2026-01-09

- Effects of simulated toss on myocardial mechanics following early burn injury in rabbits
- Journal of Army Medical University Vol. 30, Issue 8, Pages: 702-705(2008)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R331.31;R644.02;R835
- Published：2008
- 稿件说明：
移动端阅览
王广,黄跃生,罗中华,阮兢,张兵钱,肖荣,雷泽源.模拟海上颠簸刺激对严重烧伤家兔心肌力学指标的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(08):702-705.

　WANG Guang,HUANG Yue-sheng,LUO Zhong-hua,RUAN Jing,ZHANG Bing-qian,XIAO Rong,LEI Ze-yuan.Effects of simulated toss on myocardial mechanics following early burn injury in rabbits[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(08):702-705.
王广,黄跃生,罗中华,阮兢,张兵钱,肖荣,雷泽源.模拟海上颠簸刺激对严重烧伤家兔心肌力学指标的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(08):702-705. DOI：

　WANG Guang,HUANG Yue-sheng,LUO Zhong-hua,RUAN Jing,ZHANG Bing-qian,XIAO Rong,LEI Ze-yuan.Effects of simulated toss on myocardial mechanics following early burn injury in rabbits[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(08):702-705. DOI：

摘要

目的观察模拟海上颠簸刺激对烧伤早期家兔心肌力学和血流动力学指标的影响。方法 132只家兔随机分成正常对照组（N组，n=6）、单纯颠簸组(DN组，n=42)、单纯烧伤组(S组，n=42)和烧伤颠簸组(DS组，n=42)

单纯烧伤组和烧伤颠簸组造成40%全身体表面积（total body surface area

TBSA）Ⅲ度烧伤，分别于2、6、8、12、24、36、48 h等7个时相点经颈动脉左心室内置管，应用RM6240系列生理信号采集仪记录左心室压力波形和主动脉压力波形并应用RM6240系列生理信号采集处理系统处理分析相应波形，测量得出主动脉收缩压(AOSP)、主动脉舒张压(AODP) 、平均动脉压(MAP)、左心室收缩压峰值(LVSP)、左心室舒张末压(LVEDP)以及左心室内压变化最大速率(±dp/dt

max

)等心肌力学指标。结果单纯颠簸即可使家兔心肌力学指标显著降低，烧伤颠簸组心肌力学和血流动力学指标均低于单纯烧伤组。伤后2 h，烧伤颠簸组LVEDP即显著低于单纯烧伤组，LVSP、LV-dp/dt

max

自伤后6 h开始显著低于单纯烧伤组，AOSP、AODP、MAP 、LV+dp/dt

max

自烧伤后12 h开始均显著低于单纯烧伤组。结论模拟海上颠簸刺激可明显加剧严重烧伤家兔心肌力学指标的下降和心功能损害。

Abstract

Objective To investigate the effects of simulated toss on the myocardial mechanics following early burn injury in rabbits. Methods Eighty-four rabbits were subjected to 40% total body surface area thirddegree burn

and randomly divided into simple burn group (S group) and toss after burn group (DS group). There was no burn injury in another 48 rabbits

and they were randomly divided into simple toss group (DN group

n=42) and normal control group (n=6). The my

ocardial mechanic parameters (AOSP

AODP

MAP

LVSP

LVEDP and LV±dp/dt

max

) of groups DN

S and DS were investigated at 2

36 and 48 h after burn. Results The levels of AOSP

AODP

MAP

LV+dp/dt

max

in DS group were significantly lower than those of S group from 12 h after burn. The levels of LVSP and LV-dp/dt

max

in DS group were obviously lower than those of the S group from 6 h after burn. The levels of LVEDP in DS group was also predominantly lower than those of S group from 2 h after burn. The myocardial mechanic parameters in DS group were the lowest in the three experimental groups at 2

36 and 48 h after burn. Conclusion The simulated toss significantly aggravates the degression of the myocardial mechanic parameters and impairs heart function in burned rabbits.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Remote ischemic preconditioning alleviates hemodynamic changes induced by acute altitude exposure

Construction and reliability and validity of a risk assessment scale for venous thromboembolism in adult burn patients

Serum from severely burned rats promotes migration in rat bone marrow mesenchymal stem cells through PI3K/Akt signal pathway

Effects of sodium nitrite and isosorbide mononitrate on pulmonary artery pressure and pulmonary vascular remodeling in rats with high pulmonary blood flow pulmonary artery hypertension

4-phenylbutyrate protects rats against traumatic hemorrhagic shock by improving vascular function

Related Author

Yue LI

Lunli XIANG

Jiaxiang DUAN

Jianteng GU

Bin YI

Kaizhi LU

Ka CHEN

Jiaolin NING

Related Institution

Department of Anesthesiology, First Affiliated Hospital, Army Medical University (Third Military Medical University)

Research Center for Nutrition and Food Safety, Faculty of Military Preventive Medicine, Army Medical University (Third Military Medical University)

Department of High Altitude Operational Medicine, Faculty of High Altitude Military Medicine, Army Medical University (Third Military Medical University)

⁰