Design and synthesis of demethyl bryoanthrathiophene, a new potential angiogenesis inhibitor

罗圣霖; 覃容欣; 周向东

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Design and synthesis of demethyl bryoanthrathiophene, a new potential angiogenesis inhibitor

更新时间：2026-01-09

- Design and synthesis of demethyl bryoanthrathiophene, a new potential angiogenesis inhibitor
- Journal of Army Medical University Vol. 30, Issue 7, Pages: 592-594(2008)
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  CLC： {R914.2};R914.5
- Published：2008
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罗圣霖,覃容欣,周向东.血管生成抑制剂候选物——去甲苔藓蒽噻吩的设计合成[J].陆军军医大学学报(原第三军医大学学报),2008,30(07):592-594.

　LUO Sheng-lin,QIN Rong-xin,ZHOU Xiang-dong.Design and synthesis of demethyl bryoanthrathiophene, a new potential angiogenesis inhibitor[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(07):592-594.
罗圣霖,覃容欣,周向东.血管生成抑制剂候选物——去甲苔藓蒽噻吩的设计合成[J].陆军军医大学学报(原第三军医大学学报),2008,30(07):592-594. DOI：

　LUO Sheng-lin,QIN Rong-xin,ZHOU Xiang-dong.Design and synthesis of demethyl bryoanthrathiophene, a new potential angiogenesis inhibitor[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(07):592-594. DOI：

摘要

目的设计合成血管生成抑制剂候选物——去甲苔藓蒽噻吩。〖HTXBS〗方法〓〖HTSS〗以1

8-二羟基9

10-蒽醌为原料，5

7-二羟基-1-羧基-6-酮-6H-蒽[1

9-bc

]

噻吩为关键中间体，脱羧反应为关键步骤，经5步反应合成目标分子。结果以10.1%的总收率合成去甲苔藓蒽噻吩，其结构为MS、IR、UV、

H-NMR、

C-NMR和2D-NMR所证实。结论成功地合成了去甲苔藓蒽噻吩。其合成路线具有原料易得、经济高效等特点。

Abstract

Objective To design and synthesize a new potential angiogenesis inhibitor

demethyl bryoanthrathiophene. Methods Target molecule-demethyl bryoanthrathiophene was synthesized in 5 steps using 1

8-dihydroxy-9

10-anthraquinone as the starting material

7-dihydroxy-1-carboxyl-6-oxo-6H-anthra [1

9-bc] thiophene as the key intermediate and decarboxylization as the key step. Results The target molecule was synthesized with a total yield of 10.1% and identified by MS

1H-NMR

13C-NMR and 2D-NMR. Conclusion Our synthesis of demethyl bryoanthrathiophene is based on an easily-acquired starting material and accomplished with a simple synthetic route.

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覃容欣

罗圣霖

周向东

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