In vivo study on intervertebral fusion cage made by nanohydroxyapatite and ployamide66 composites

梁勇; 蒋电明

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In vivo study on intervertebral fusion cage made by nanohydroxyapatite and ployamide66 composites

更新时间：2026-01-09

- In vivo study on intervertebral fusion cage made by nanohydroxyapatite and ployamide66 composites
- Journal of Army Medical University Vol. 29, Issue 24, Pages: 2333-2335(2007)
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  CLC： R-332;R681.505;R687.3
- Published：2007
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梁勇,蒋电明.纳米羟基磷灰石/聚酰胺66椎间融合器对山羊颈椎的融合效果研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(24):2333-2335.

　LIANG Yong,JIANG Dian-ming.In vivo study on intervertebral fusion cage made by nanohydroxyapatite and ployamide66 composites[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(24):2333-2335.
梁勇,蒋电明.纳米羟基磷灰石/聚酰胺66椎间融合器对山羊颈椎的融合效果研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(24):2333-2335. DOI：

　LIANG Yong,JIANG Dian-ming.In vivo study on intervertebral fusion cage made by nanohydroxyapatite and ployamide66 composites[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(24):2333-2335. DOI：

摘要

目的研究纳米羟基磷灰石/聚酰胺66(n-HA/PA66)复合生物活性椎间融合器对山羊颈椎的融合效果和可行性。方法取30只成年雌性山羊，按随机数字表分为2组：n-HA/PA66复合生物活性椎间融合器组和自体髂骨组。所有山羊行颈3、4椎间盘及部分椎体切除术，分别植入n-HA/PA66复合生物活性椎间融合器和自体髂骨块，术后4、12、24周行CT检查；术后12、24周行组织学和生物力学评估。结果 24周时n-HA/PA66椎间融合器与自体髂骨在山羊颈3、4椎间均可形成骨性融合，组织学、影像学及生物力学等各项测试指标比较，差异均无统计学意义（P0.05）。结论 n-HA/PA66椎间融合器具有良好的骨传导性和生物力学特性，达到了良好的融合效果，是一种理想的椎间融合材料。

Abstract

Objective To evaluate the characteristics of fusion by using biomimetic nano-hydroxyapatite and ployamide66 composites (n-HA/PA66) interbody cage. Methods Thirty adult female goats underwent c3-4 discectomy and intervertebral fusion with n-HA/PA66 interbody cage (n=15) or autogenous iliac crest bone graft (n=15). CT scanning was performed at 4th

12th and 24th week after surgery to evaluate fusion. After the goats were killed respectively on the 12th and 24th week

nondestructive biomechanical test for stiffness

undecalcified histology were performed. Results The goats receiving n-HA/PA66 or autograft all showed complete fusion at 24th week

without statistically significant differience upon biomechanics

radiography and histomorphology (P0.05). Conclusion The intervertebral fusion cage of n-HA/PA66 has good biocompatibility and osteo-conductibility. It may be the ideal interbody fusion cage.

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