Relationship of Cyr61 and β-catenin in hepatocellular carcinoma tissues and hepatoma carcinoma cells

孙世俊; 司维柯; 丁伟; 潘静; 李招权; 赵宸

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Relationship of Cyr61 and β-catenin in hepatocellular carcinoma tissues and hepatoma carcinoma cells

更新时间：2026-01-09

- Relationship of Cyr61 and β-catenin in hepatocellular carcinoma tissues and hepatoma carcinoma cells
- Journal of Army Medical University Vol. 30, Issue 6, Pages: 485-488(2008)
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  CLC： R341;R394.3;R735.7
- Published：2008
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孙世俊,司维柯,丁伟,潘静,李招权,赵宸.Cyr61与β-catenin在肝癌组织和细胞株中表达的相关性研究[J].陆军军医大学学报(原第三军医大学学报),2008,30(06):485-488.

　SUN Shi-jun,SI Wei-ke,DING Wei,PAN Jing,LI Zhao-quan,ZHAO Chen.Relationship of Cyr61 and β-catenin in hepatocellular carcinoma tissues and hepatoma carcinoma cells[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(06):485-488.
孙世俊,司维柯,丁伟,潘静,李招权,赵宸.Cyr61与β-catenin在肝癌组织和细胞株中表达的相关性研究[J].陆军军医大学学报(原第三军医大学学报),2008,30(06):485-488. DOI：

　SUN Shi-jun,SI Wei-ke,DING Wei,PAN Jing,LI Zhao-quan,ZHAO Chen.Relationship of Cyr61 and β-catenin in hepatocellular carcinoma tissues and hepatoma carcinoma cells[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(06):485-488. DOI：

摘要

目的研究Cyr61与β-catenin在肝细胞肝癌和肝癌细胞株中的表达及其相关性，探讨二者在肝癌发生中的作用。方法采用免疫组化法检测32例肝细胞肝癌患者肝癌组织中Cyr61与β-catenin蛋白的表达水平；免疫组化法和RT-PCR检测正常肝细胞株L02和肝癌细胞株HepG

、QGY-7701、H

中Cyr61与β-catenin蛋白与mRNA的表达水平；并比较二者的相关性。结果 65.63%（21/32）肝癌标本Cyr61蛋白阳性表达，71.88%（23/32）肝癌标本β-catenin蛋白阳性表达，二者合并阳性表达有56.25%（18/32），合并阴性表达有18.75%（6/32），Cyr61表达与β-catenin表达呈正相关（r=0.425

P0.05）；正常肝细胞株L02及肝癌细胞株HepG

、QGY-7701、H

中Cyr61 与 β-catenin mRNA与蛋白均有表达，二者表达一致性达100%。结论 Cyr61与β-catenin在肝癌和肝癌细胞株中高度一致阳性表达，提示Cyr61的表达可能与β-catenin的表达有关，二者可能在肝癌的发生中起到重要作用。

Abstract

Objective To investigate expressions of Cyr61 and β-catenin and their relationship in hepatocellular carcinoma tissues and hepatoma carcinoma cells

and explore their roles in hepatocarcinogenesis. Methods Expressions of Cyr61 and β-catenin were studied by immunohistochemistry in 32 patients with hepatocellular carcinoma

hepatocyte L02 and hepatoma carcinoma cell HepG

QGY-7701 and H

cells. Cyr61 mRNA and β-catenin mRNA were detected by RTPCR in hepatocyte L02 and hepatoma

carcinoma cell HepG

QGY-7701 and H

cells. The relationship of their expressions were studied. Results The expressions of Cyr61 protein and β-catenin protein were found in 65.63%（21/32） and 71.88%（23/32）of 32 patients

both Cyr61 protein and βcatenin protein were negatively expressed detected in 18.75% （6/32）and positively in 56.25%（18/32） respectively. Expression of Cyr61 protein was positively correlated with the expression of β-catenin protein (r=0.425

P0.05). Expressions of Cyr61 and β-catenin at both mRNA and protein levels were found in hepatocyte L02 and hepatoma carcinoma cell HepG

QGY-7701

co-expression of Cyr61 and β-catenin was 100% of all cells. Conclusion Cyr61 and β-catenin are expressed in hepatocellular carcinoma tissues and hepatoma carcinoma cells. Expression of Cyr61 is related with expression of β-catenin

and they may participate in hepatocarcinogenesis.

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