Prediction of B-cell antigen epitope on lipopolysaccharidebinding protein

冯起甲; 徐智; 吴国明; 胡川闽; 徐顺贵; 陈维中; 郭芮伶

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Prediction of B-cell antigen epitope on lipopolysaccharidebinding protein

更新时间：2026-01-09

- Prediction of B-cell antigen epitope on lipopolysaccharidebinding protein
- Journal of Army Medical University Vol. 30, Issue 4, Pages: 292-294(2008)
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  CLC： R318.04;R392.1;R392.2
- Published：2008
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冯起甲,徐智,吴国明,胡川闽,徐顺贵,陈维中,郭芮伶.脂多糖结合蛋白的B细胞抗原表位预测及其效应初步分析[J].陆军军医大学学报(原第三军医大学学报),2008,30(04):292-294.

　FENG Qi-jia,XU Zhi WU Guo-ming,HU Chuan-min,XU Shun-gui,CHEN Wei-zhong,GUO Rui-ling.Prediction of B-cell antigen epitope on lipopolysaccharidebinding protein[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(04):292-294.
冯起甲,徐智,吴国明,胡川闽,徐顺贵,陈维中,郭芮伶.脂多糖结合蛋白的B细胞抗原表位预测及其效应初步分析[J].陆军军医大学学报(原第三军医大学学报),2008,30(04):292-294. DOI：

　FENG Qi-jia,XU Zhi WU Guo-ming,HU Chuan-min,XU Shun-gui,CHEN Wei-zhong,GUO Rui-ling.Prediction of B-cell antigen epitope on lipopolysaccharidebinding protein[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(04):292-294. DOI：

摘要

目的预测人脂多糖结合蛋白(LBP)的B 细胞抗原表位。方法采用生物信息软件和互联网服务器，预测LBP的二级结构和分析LBP表面特性（亲水性、可塑性、可及性和抗原性），再计算平均抗原指数(AI)，预测LBP 的B细胞抗原表位。结果 LBP 存在多个潜在的抗原表位，247~260序列（FKGEIFHRNHRSPV）的AI（0.040 7）明显高于其他片段，370~379序列（LPSSSKEPVF）和303~325序列（ITDDMIPPDSNIRLTTKSFRPFV）的AI分别是0.033 6和0.029 5。247~260 序列是LBP 潜在的B 细胞优势抗原表位。结论应用多参数预测到LBP的B细胞抗原表位。

Abstract

Objective To predict the B-cell epitope for lipopolysaccharide-binding protein (LBP) antigen. Methods Using biotic software and network servers

the secondary structure of LBP was predicted

and the surface properties of LBP

such as hydrophilicity

flexibility

accessibility and antigenicity

were analyzed. Then the average antigen index (AI) was calculated by using Wu’s method. Results Many distinct antigenic epitopes on LBP were identified: AI of sequence 247-260 (FKGEIFHRNHRSPV) on LBP was 0.040 7

significantly higher than that of other sequences. AI of sequence 370-379 (LPSSSKEPVF) and sequence 303-325 (ITDDMIPPDSNIRLTTKSFRPFV) was 0.033 6 and 0.029 5

respectively. Sequence 247-260 was the prevalent antigen epitope of Bcell on LBP. Conclusion The B-cell epitopes of LBP is predicted successfully.

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Related Institution

Department of Gastroenterology， Chongqing University Cancer Hospital

Department of Gastroenterology， Chongqing Key Laboratory of Precise Prevention and Treatment of Digestive Malignancies， Army Medical Center of PLA/Daping Hospital of Third Military Medical University

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School of Medicine， Chongqing University

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