Heparanase expression in bladder transitional cell carcinoma and its correlation with clinical pathological features

鄢俊安; 宋波; 陈志文; 宋彩萍

您当前的位置：

首页 >

文章列表页 >

Heparanase expression in bladder transitional cell carcinoma and its correlation with clinical pathological features

更新时间：2026-01-09

- Heparanase expression in bladder transitional cell carcinoma and its correlation with clinical pathological features
- Journal of Army Medical University Vol. 29, Issue 23, Pages: 2280-2282(2007)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R345;R730.23;R737.14
- Published：2007
- 稿件说明：
移动端阅览
鄢俊安,宋波,陈志文,宋彩萍.乙酰肝素酶在膀胱移行细胞癌中的表达及与临床特征的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(23):2280-2282.

　YAN Jun-an,SONG Bo,CHEN Zhi-wen,SONG Cai-ping.Heparanase expression in bladder transitional cell carcinoma and its correlation with clinical pathological features[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(23):2280-2282.
鄢俊安,宋波,陈志文,宋彩萍.乙酰肝素酶在膀胱移行细胞癌中的表达及与临床特征的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(23):2280-2282. DOI：

　YAN Jun-an,SONG Bo,CHEN Zhi-wen,SONG Cai-ping.Heparanase expression in bladder transitional cell carcinoma and its correlation with clinical pathological features[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(23):2280-2282. DOI：

摘要

目的探讨乙酰肝素酶（heparanase，HPA）在膀胱移行细胞癌中的表达及与肿瘤临床病理特征的关系。方法应用逆转录-聚合酶链反应（RT-PCR）及免疫组织化学方法检测68例膀胱移行细胞癌、24例癌旁组织中HPA mRNA的水平及蛋白表达定位，并结合患者临床病理指标及预后进行分析。结果 68例膀胱移行细胞癌组织中HPA mRNA检出阳性41例（60.3%），24例癌旁组织中HPA mRNA检出阳性1例（4.2%），两组间差异有统计学意义（P0.01），HPA mRNA的表达在膀胱移行细胞癌不同病理分级、临床分期及淋巴结转移与否分组中显著不同（P0.01）。免疫组化结果显示，HPA定位于细胞质及细胞核，阳性率为77.9%（53例），在膀胱移行细胞癌淋巴结转移与否分组中显著不同（P001）。结论 HPA在膀胱移行细胞癌的生长浸润、侵袭转移中可能发挥重要作用。

Abstract

Objective To explore the expression of heparanase (HPA) and its correlation with the clinical pathological features and angiogenesis in bladder transitional cell carcinoma. Methods HPA mRNA level was detected with RT-PCR and its protein level was determined by immunohistochemical staining in 68 cases of bladder cancer and 24 cases of adjacent tissues of bladder cancer. Results The positive rate of HPA mRNA was 60.3% (41/68) in bladder cancer

4.2% (1/24) in the adjacent tissues of bladder cancer. The expression of HPA mRNA had statistically significant correlation with pathological stage

clinical staging and lymphonode metastasis (P0.01). Immunohistochemistry showed HPA located in the cytoplasm and nucleus of bladder cancer and its positive rate was 77.9% (53/68). In addition

HPA protein levels were statistically different in the cases with and without lymphonode metastasis (P0.01). Conclusion HPA may play an important role in the growth

invasion and metastasis of bladder cancer. HPA was a useful marker of the biological behavior of bladder cancer and an independent prognosis factor of bladder cancer.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Expressions of cyclooxygenase-2 and epidermal growth factor receptor in transitional cell carcinoma of bladder and their correlation

Expression of P504s and claudin-4 in prostate cancer and prognostic value of their combined detection

Expression and clinical significance of pyruvate dehydrogenase kinase 4 in colon cancer

Expression and clinical significance of S100A4 and SEPT7 in childhood gliomas

Prognostic significance of chondroitin sulfate proteoglycan 4 over-expression in pancreatic cancer patients

Related Author

梁平

靳风烁

吴刚

李增鹏

张沁宏

林俐

Gang BI

Chengyi MAO

Related Institution

Department of Urology, Army Medical University (Third Military Medical University)

Department of Pathology, Daping Hospital, Army Medical University (Third Military Medical University)

⁰