Protein microarray for simultaneous detection of pathogens in blood transfusion

黄敏; 张敏丽; 蒲晓允

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Protein microarray for simultaneous detection of pathogens in blood transfusion

更新时间：2026-01-09

- Protein microarray for simultaneous detection of pathogens in blood transfusion
- Journal of Army Medical University Vol. 29, Issue 21, Pages: 2080-2082(2007)
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  CLC： R319;R446.11
- Published：2007
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黄敏,张敏丽,蒲晓允.微阵列检测血样感染相关四项指标的实验研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(21):2080-2082.

　HUANG Min,ZHANG Min-li,PU Xiao-yun.Protein microarray for simultaneous detection of pathogens in blood transfusion[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(21):2080-2082.
黄敏,张敏丽,蒲晓允.微阵列检测血样感染相关四项指标的实验研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(21):2080-2082. DOI：

　HUANG Min,ZHANG Min-li,PU Xiao-yun.Protein microarray for simultaneous detection of pathogens in blood transfusion[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(21):2080-2082. DOI：

摘要

目的利用蛋白芯片技术检测血样感染相关四项指标，并与ELISA酶联免疫技术进行客观分析评价。方法对230份国家参比品同时进行蛋白芯片与ELISA酶联免疫的检测，并观察蛋白芯片对诊断血样感染四项指标的敏感性和特异性。结果用统计学的配对计数资料检验得出：χ

=0.5，P=0.125，说明两种方法检测结果无统计学差异。结论蛋白微阵列检测结果无论是与参比品本身还是与ELISA试剂盒都有极高的符合率，是一种很有发展前途的检验技术。

Abstract

Objective To study the diagnostic value of multiplex protein microarray and ELISA for human serum pathogens. Methods Totally 230 national standard samples were tested by multiplex protein microarray and ELISA respectively for the pathogens of HBV

HIV

HCV and treponema pallidum (TP). Results The matched pair test for numeration data showed χ

=0.5

P=0.125

indicating that no statistical significance between the two methods. Conclusion Multiplex protein microarray shows high specificity and sensitivity to the four pathogens so that it is worth extensive application.

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Related Institution

First Affiliated Hospital， Air Force Medical University

Key Laboratory of Molecular Biology for Infectious Diseases of Ministry of Education， Chongqing Medical University

Institute of Infectious Diseases, Chongqing Key Laboratory of Infectious Diseases Research, First Affiliated Hospital, Army Medical University (Third Military Medical University)

Department of Clinical Laboratory, the Second Affiliated Hospital of Chongqing Medical University

Key Laboratory of Molecular Biology on Infectious Diseases of Ministry of Education, Chongqing Medical University

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