Minocycline inhibits COX-2 and NF-κB expressions in rats of focal cerebral ischemia-reperfusion

蔡志友; 余昌胤; 晏勇; 张骏; 黄良国; 袁胜山; 王凤英

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Minocycline inhibits COX-2 and NF-κB expressions in rats of focal cerebral ischemia-reperfusion

更新时间：2026-01-09

- Minocycline inhibits COX-2 and NF-κB expressions in rats of focal cerebral ischemia-reperfusion
- Journal of Army Medical University Vol. 29, Issue 21, Pages: 2067-2069(2007)
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  CLC： R741.02;R743.31;R978.14
- Published：2007
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蔡志友,余昌胤,晏勇,张骏,黄良国,袁胜山,王凤英.美满霉素对脑缺血再灌注大鼠脑组织COX-2、NF-κB表达的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(21):2067-2069.

　CAI Zhi-you,YU Chang-yin,YAN Yong,ZHANG Jun,HUANG Liang-guo,YUAN Sheng-shan,WANG Feng-ying.Minocycline inhibits COX-2 and NF-κB expressions in rats of focal cerebral ischemia-reperfusion[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(21):2067-2069.
蔡志友,余昌胤,晏勇,张骏,黄良国,袁胜山,王凤英.美满霉素对脑缺血再灌注大鼠脑组织COX-2、NF-κB表达的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(21):2067-2069. DOI：

　CAI Zhi-you,YU Chang-yin,YAN Yong,ZHANG Jun,HUANG Liang-guo,YUAN Sheng-shan,WANG Feng-ying.Minocycline inhibits COX-2 and NF-κB expressions in rats of focal cerebral ischemia-reperfusion[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(21):2067-2069. DOI：

摘要

目的观察美满霉素对脑缺血再灌注大鼠COX-2、NF-κB表达的影响。方法 54只Wistar大鼠，适应性喂养1周，分为：正常组（N组）、假手术组（NS组）、美满霉素对照组（M组）、美满霉素预处理组（MP组），美满霉素治疗组（MT组），缺血再灌注组（IR组）。HE染色观察大鼠脑组织的病理改变；采用免疫组织化学法检测大鼠脑组织COX-2、NF-κB的表达，用图像分析仪测定光密度值。结果 NF-κB p65和COX-2光密度值、阳性细胞百分率MP组较NS组明显增高（P0.01），较IR组明显降低（P0.01）。MT组较NS组明显增高（P0.01），较IR组明显降低（P0.05）。结论美满霉素能抑制大鼠脑缺血再灌注后脑组织COX-2、NF-κB的表达，发挥脑保护作用。

Abstract

Objective To observe the influence of minocycline on the expressin of COX-2

NF-κB in the rats of focal cerebral ischemia-reperfusion (I/R). Methods Fifty-four healthy Wistar rats were randomly divided into normal group (N)

sham-operation group (NS)

minocycline group (M)

minocycline preconditioning group (MP) in which the rats were intragastrically administered with minocycline 30 min before I/R and respectively ischemia for 12 and 24 h; minocycline treatment group (MT) in which the rats were intragastrically administered with minocycline after ischemia for 12 or 24 h and reperfusion

IR group. The expressions of COX-2 and NF-κB were measured by immunohistochemistry. The light density value was measured by image analyzer. Results The light density values and cell positive rates of NF-κB and COX-2 after reperfusion in MP and MT group were significantly higher than that of in NS group (P0.01) and obviously less than that of in IR group (P0.05). Conclusion Minocycline can decrease the expression of COX-2

NF-κB in rats with focal cerebral ischemia-reperfusion to protect brain function.

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