Highly efficient synthesis of methyl bryoanthrathiophene-1-carboxylate

覃容欣; 罗圣霖; 周向东

您当前的位置：

首页 >

文章列表页 >

Highly efficient synthesis of methyl bryoanthrathiophene-1-carboxylate

更新时间：2026-01-09

- Highly efficient synthesis of methyl bryoanthrathiophene-1-carboxylate
- Journal of Army Medical University Vol. 29, Issue 22, Pages: 2124-2127(2007)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R914
- Published：2007
- 稿件说明：
移动端阅览
覃容欣,罗圣霖,周向东.苔藓蒽噻吩-1-羧酸甲酯的合成[J].陆军军医大学学报(原第三军医大学学报),2007,29(22):2124-2127.

　QIN Rong-xin,LUO Sheng-lin,ZHOU Xiang-dong.Highly efficient synthesis of methyl bryoanthrathiophene-1-carboxylate[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(22):2124-2127.
覃容欣,罗圣霖,周向东.苔藓蒽噻吩-1-羧酸甲酯的合成[J].陆军军医大学学报(原第三军医大学学报),2007,29(22):2124-2127. DOI：

　QIN Rong-xin,LUO Sheng-lin,ZHOU Xiang-dong.Highly efficient synthesis of methyl bryoanthrathiophene-1-carboxylate[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(22):2124-2127. DOI：

摘要

目的高效合成目标分子苔藓蒽噻吩-1-羧酸甲酯。方法以1，8-二羟基-9，10-蒽醌为原料，经过保护、硝化、巯代、环合和脱保护5步反应，合成目标分子。结果以45.8%的总收率合成目标分子。结论高效合成了苔藓蒽噻吩-1-羧酸甲酯。本方法具有合成路线短、选择性好和合成效率高等特点。

Abstract

Objective To study the synthesis of methyl bryoanthrathiophene-1-carboxylate with high efficiency. Methods Target compounds were synthesized from 1

8-dihydroxy-9

10-anthraquinone via 5 steps including protecting

nitration

methyl mercaptoacetate substitution

intramolecular Aldol reaction and deprotecting. Results Target molecule was synthesized in the total yield of 45.8%. Conclusion Our synthesis of methyl bryoanthrathiophene-1-carboxylate is characterized by short synthetic route

high selectivity and high efficiency.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Design and synthesis of demethyl bryoanthrathiophene, a new potential angiogenesis inhibitor

Related Author

罗圣霖

覃容欣

周向东

Related Institution

No data

⁰