Relationship of estrogen receptor-beta and its isoform expressions with tamoxifen resistance in human breast cancer

周艳; 姜军; 张毅; 凡庆东; 范林军; 梁燕; 徐鹰妮

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Relationship of estrogen receptor-beta and its isoform expressions with tamoxifen resistance in human breast cancer

更新时间：2026-01-09

- Relationship of estrogen receptor-beta and its isoform expressions with tamoxifen resistance in human breast cancer
- Journal of Army Medical University Vol. 29, Issue 20, Pages: 1999-2001(2007)
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  CLC： R737.9;R969.2;R977
- Published：2007
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周艳,姜军,张毅,凡庆东,范林军,梁燕,徐鹰妮.雌激素受体β及其剪切变异体表达与雌激素受体阻滞剂治疗耐药的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(20):1999-2001.

　ZHOU Yan,JIANG Jun,ZHANG Yi,FAN Qing-dong,FAN Lin-jun,LIANG Yan,XU Ying-ni.Relationship of estrogen receptor-beta and its isoform expressions with tamoxifen resistance in human breast cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(20):1999-2001.
周艳,姜军,张毅,凡庆东,范林军,梁燕,徐鹰妮.雌激素受体β及其剪切变异体表达与雌激素受体阻滞剂治疗耐药的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(20):1999-2001. DOI：

　ZHOU Yan,JIANG Jun,ZHANG Yi,FAN Qing-dong,FAN Lin-jun,LIANG Yan,XU Ying-ni.Relationship of estrogen receptor-beta and its isoform expressions with tamoxifen resistance in human breast cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(20):1999-2001. DOI：

摘要

目的探讨雌激素受体β及其剪切变异体表达与乳腺癌他莫昔分治疗耐药的关系。方法选取接受他莫昔分治疗期间出现疾病进展的13例病例作为他莫昔分抵抗组，另外选取在年龄、绝经状态、随访时间、肿瘤分级分期和组织学表现上均接近，但是接受他莫昔分治疗期间未出现疾病进展的同样13例患者作为他莫昔分敏感组。采用免疫组化方法检测总ERβ、ERβ1 和ERβcx蛋白的表达。结果总ERβ表达在他莫昔分抵抗组和敏感组之间有显著性差异（P0.05），总ERβ蛋白水平在他莫昔分敏感组明显高于他莫昔分抵抗组。ERβ1和ERβcx蛋白表达水平在2组间没有显著性差异。结论在预测内分泌治疗敏感性时，总ERβ以及ERβ异构型将和ERα状态一起，可能扮演重要角色，需要更大样本的前瞻性实验进行深入研究。

Abstract

Objective To study the relationship of estrogen receptor-beta and its isoform expressions with tamoxifen resistance in human breast cancer. Methods Thirty patients of primary breast cancer whose disease progressed while on tamoxifen therapy (tamoxifen resistant) and 13 matched patients of primary breast cancer without disease progression (tamoxifen sensitive) were included. The expression of total estrogen receptor beta (ERβ)

ERβ1 and ERβcx in the specimens were tested by IHC. Results High total ERβ protein expressions were more in tamoxifen sensitive tumors than resistant tumors (P0.05)

while the expressions of ERβ1 and ERβcx protein showed no significant differences between the two groups. Conclusion The expressions of ERβ protein and its isoforms may differ in breast cancer patients who have different sensitivity to tamoxifen therapy.

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