Effect of serotonin on subdiaphragmatic vagus nerve afferent discharge and its mechanism in rats

隋红; 陈卫; 陆杰

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Effect of serotonin on subdiaphragmatic vagus nerve afferent discharge and its mechanism in rats

更新时间：2026-01-09

- Effect of serotonin on subdiaphragmatic vagus nerve afferent discharge and its mechanism in rats
- Journal of Army Medical University Vol. 29, Issue 17, Pages: 1706-1708(2007)
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  CLC： R329.26;R338;R338.8
- Published：2007
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隋红,陈卫,陆杰.5-羟色胺对大鼠膈下迷走神经传入放电的影响及机制[J].陆军军医大学学报(原第三军医大学学报),2007,29(17):1706-1708.

　SUI Hong,CHEN Wei,LU Jie.Effect of serotonin on subdiaphragmatic vagus nerve afferent discharge and its mechanism in rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(17):1706-1708.
隋红,陈卫,陆杰.5-羟色胺对大鼠膈下迷走神经传入放电的影响及机制[J].陆军军医大学学报(原第三军医大学学报),2007,29(17):1706-1708. DOI：

　SUI Hong,CHEN Wei,LU Jie.Effect of serotonin on subdiaphragmatic vagus nerve afferent discharge and its mechanism in rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(17):1706-1708. DOI：

摘要

目的探讨大鼠外周静脉注射5-羟色胺以及促胰液素(secretin， SEC)对膈下迷走神经传入冲动的影响

以及5-羟色胺对膈下迷走神经传入冲动影响的机制。方法采用电生理学方法记录膈下迷走神经传入自发放电为观察指标，观察外周静脉注射不同剂量的5-HT（3、10、30 μg/kg）、5-HT

受体的拮抗剂格拉司琼（1 mg/kg）以及5-HT+SEC对其的影响。结果 5-HT对膈下迷走神经传入自发放电具有兴奋作用，给予5-HT

受体拮抗剂后神经放电的效应被抑制，大剂量5-羟色胺+促胰液素可增强由单独的大剂量5HT所致的迷走神经传入放电的兴奋作用。结论 5-HT可能是作用于与迷走传入相关的5-HT

受体兴奋了膈下迷走传入神经自发放电；促胰液素可以增强5-HT对迷走神经传入自发放电的兴奋作用。

Abstract

Objective To investigate the effect and mechanism of serotonin (5-HT) and secretin(SEC) on afferent discharge of vagus in rats. Methods Spontaneous afferent discharge of subdiaphragmatic vagus nerve was recorded in urethane anesthetized rats. The effects of 5-HT

5-HT

receptor antagonist and 5-HT+SEC on the discharge of subdiaphragmatic vagus nerve were investigated by intravenous injection of different dosage of 5-HT(3

30 μg/kg)

Granisetron (1 mg/kg) and 5-HT+SEC. Results Intravenous 5-HT caused obvious exciting effect on spontaneous afferent discharge of subdiaphragmatic vagus nerve. The 5-HT

receptor antagonist signific

antly inhibited the effects of 5-HT. 5-HT+SEC could augment the effect of 5-HT on spontaneous discharge. Conclusion The exciting effect of 5-HT on afferent discharge of subdiaphragmatic vagus nerve is possibly mediated by 5-HT

receptor related to vagus nerve afference. Secretin can augment the exciting effect of 5-HT on spontaneous discharge of vagus afferent nerve.

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