Correlation between expression of lung resistance-related protein in non-small cell lung cancer and that in peripheral blood lymphocytes

闵发胜; 陈正堂

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Correlation between expression of lung resistance-related protein in non-small cell lung cancer and that in peripheral blood lymphocytes

更新时间：2026-01-09

- Correlation between expression of lung resistance-related protein in non-small cell lung cancer and that in peripheral blood lymphocytes
- Journal of Army Medical University Vol. 29, Issue 17, Pages: 1699-1701(2007)
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  CLC： R341;R730.23;R734.2
- Published：2007
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闵发胜,陈正堂.人非小细胞肺癌与外周血淋巴细胞表达LRP的相关性研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(17):1699-1701.

　MIN Fa-sheng,CHEN Zheng-tang.Correlation between expression of lung resistance-related protein in non-small cell lung cancer and that in peripheral blood lymphocytes[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(17):1699-1701.
闵发胜,陈正堂.人非小细胞肺癌与外周血淋巴细胞表达LRP的相关性研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(17):1699-1701. DOI：

　MIN Fa-sheng,CHEN Zheng-tang.Correlation between expression of lung resistance-related protein in non-small cell lung cancer and that in peripheral blood lymphocytes[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(17):1699-1701. DOI：

摘要

目的探讨肺耐药相关蛋白(lung resistance-related protein

LRP)在人非小细胞肺癌(non-small cell lung cancer

NSCLC)癌组织、癌旁组织和外周血淋巴细胞(peripheral blood lymphocytes

PBL)中的表达及其相关性。方法采用S-P免疫组织化学方法检测49例人NSCLC癌组织、癌旁组织和 PBL中LRP的表达及10例正常人PBL中LRP的表达。结果 NSCLC癌组织、癌旁组织和PBL的LRP表达阳性率分别为78.2%、46.4%和66.8%，其中癌组织的LRP表达阳性率明显高于癌旁组织(P＜0.05)，且与PBL的LRP表达呈正相关。在各病理类型的NSCLC中，腺癌表达阳性率最高(90.9％)，鳞癌次之(55.6％)，差异显著(P＜0.01)。10例正常人PBL的LRP表达阳性率(20%)显著低于NSCLC患者(P＜0.05)。结论检测NSCLC患者PBL的LRP表达可间接反映癌组织的LRP表达状况。

Abstract

Objective To explore the correlation between the expression of lung resistance-related protein (LRP) in non-small cell lung cancer (NSCLC) and that in peripheral blood lymphocytes (PBL). Methods The S-P immunohistochemistry was used to detect the expression of LRP in specimens and PBL of 49 patients with NSCLC. Para-carcinoma tissues and PBL of 10 normal people were used as controls. Results The positive expression rate of LRP was 78.2%

46.4% and 66.8% in carcinoma tissues

para-carcinoma tissues and PBL

respectively. The expression rate of LRP in carcinoma tissues was higher than that in para-carcinoma tissues (P＜0.05)

and positively correlated with that in PBL of the patients. The expression rate of LRP in adenocarcinomas was higher than that in squamous cell carcinomas (P＜0.01). The expression rate of LRP in the normal people was lower than in NSCLC patients(P＜0.05). Conclusion The expression of LRP in PBL of NSCLC patients may indirectly represent the expression of LRP in carcinoma tissues.

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