Objective    To investigate the hemostatic effects and safety of the QuGouCao chloroform-water extract.      Methods    The hemostatic property of the extract was studied by applying the extract soaked gauze to the local wound surface of skin

liver and femoral artery in rabbits. LD

50

test in Kuming mice was performed and the tissues of liver and kidney were collected for routine histochemical examination. The skin stimulus in rabbits and the sensitivity test in guinea pigs were conducted.      Results    The hemostatic time of wounds was obviously shorter (P0.01) than that of blank group control. LD

50

was 483.08 mg/kg. The liver and kidney of toxicated mice were normal when the extract less than 300 mg/kg. 10% QuGouCao chloroform-water extract had no stimul

ation effect on the intact skin or damaged skin as well as caused no allergic or toxic reaction.     Conclusion    The QuGouCao chloroform-water extract has good hemostatic effect on the local wound surfaces. It is of low toxicity

few side effects and safety.