Expression and clinical significance of P-gp，GST-π，and TopoⅡ in esophagus cancer

唐郡; 阎晓初; 彭贵勇; 孙永刚; 程龙; 陈春燕

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Expression and clinical significance of P-gp，GST-π，and TopoⅡ in esophagus cancer

更新时间：2026-01-09

- Expression and clinical significance of P-gp，GST-π，and TopoⅡ in esophagus cancer
- Journal of Army Medical University Vol. 29, Issue 17, Pages: 1692-1695(2007)
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  CLC： R341;R730.23;R735.1
- Published：2007
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唐郡,阎晓初,彭贵勇,孙永刚,程龙,陈春燕.食管鳞状细胞癌P-gp、GST-π、TopoⅡ的表达及临床意义[J].陆军军医大学学报(原第三军医大学学报),2007,29(17):1692-1695.

　TANG Jun,YAN Xiao-chu,PENG Gui-yong,SUN Yong-gang,CHENG Long,CHEN Chun-yan.Expression and clinical significance of P-gp，GST-π，and TopoⅡ in esophagus cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(17):1692-1695.
唐郡,阎晓初,彭贵勇,孙永刚,程龙,陈春燕.食管鳞状细胞癌P-gp、GST-π、TopoⅡ的表达及临床意义[J].陆军军医大学学报(原第三军医大学学报),2007,29(17):1692-1695. DOI：

　TANG Jun,YAN Xiao-chu,PENG Gui-yong,SUN Yong-gang,CHENG Long,CHEN Chun-yan.Expression and clinical significance of P-gp，GST-π，and TopoⅡ in esophagus cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(17):1692-1695. DOI：

摘要

目的探讨耐药基因蛋白P-gp、GST-π和TopoⅡ在食管鳞状细胞癌及正常食管组织中的表达及其与临床病理的关系。方法应用免疫组织化学方法检测144例手术切除的食管鳞状细胞癌组织和30例正常食管组织中P-gp、GST-π和TopoⅡ的表达。结果 P-gp、GST-π、TopoⅡ的表达与患者年龄、性别、淋巴结转移、肿瘤大小及浸润深度无关（P0.05），与肿瘤的分化程度有关，高分化、中分化和低分化鳞癌组间比较差异有统计学意义(P＜0.05)。结论食管鳞状细胞癌耐药由多种耐药基因共同参与，联合检测多项耐药相关蛋白表达，对指导临床化疗药物选择具有意义。

Abstract

Objective To investigate the expression of P-gp

GST-π

and TopoⅡ， as well as its relationship with clinical pathologic characteristics of esophageal squamous cell carcinoma. Methods Totally 144 tissue samples of esophagus squamous cell carcinoma and 30 normal esophagus tissues were examined for the expression of P-gp

GST-π

and TopoⅡby immunohistochemistry. Results The expression of P-gp

GST-π

and TopoⅡwas not associated with patients′ age， gender， lymph node metastasis， tumor size， and infiltration depth but with cellular differentiation. On this aspect

there was significant difference among well-

moderately

or poorly differentiated squamous cell carcinomas (P＜0.05) . Conclusion P-gp， GST-π

and TopoⅡ play an important role in multidrug resistance. Detecting the expression of P-gp， GST-π

and TopoⅡ has an important significance in chemotherapy for esophagus squamous cell carcinoma.

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