Objective    To analyze the dynamic changes of vision acuity

refraction and corneal topography after LASIK for anisometropia of high myopia in children.     Methods    Forty-one patients aged 6 to 14 years old (42 eyes) with anisometropia of high myopia underwent LASIK

and vision acuity

refraction and corneal topography were evaluated at postoperative 1

3

6

12 months during follow up.     Results    The average uncorrected and best corrected distance vision acuity after surgery was better than that before operation. The average decrease of equivalent value of simulated keratoscope reading (Sim k) and spherical refraction were 6.50D and 8.25D in postoperative 1 month

decreased within 3 months

still decreased slightly from 3 to 6 month and stabilized from 6 to 12 month. The margin of Sim k accorded with the changes of the cylindrical refraction

decreased significantly after surgery and had no significant changes in different periods.      Conclusion    The visual acuity recovers quickly after LASIK for anisometropia of high myopia in children. The corneal topography could display the modality of cornea accurately that was similar to adults’ but of its own characteristics. The corneal topography is of clinical importance for the improvement and predictability of surgery.