The study of the protection of telmisartan on the cognitive function in diabetic rats

高原; 肖谦; 赵柯湘; 吴绮楠; 李龙英; 高爱滨; 张海娜

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The study of the protection of telmisartan on the cognitive function in diabetic rats

更新时间：2026-01-09

- The study of the protection of telmisartan on the cognitive function in diabetic rats
- Journal of Army Medical University Vol. 29, Issue 15, Pages: 1514-1516(2007)
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  CLC： R338.64;R587.205;R977.1
- Published：2007
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高原,肖谦,赵柯湘,吴绮楠,李龙英,高爱滨,张海娜.替米沙坦对糖尿病大鼠认知功能的保护作用[J].陆军军医大学学报(原第三军医大学学报),2007,29(15):1514-1516.

　GAO Yuan,XIAO Qian,ZHAO Ke-Xiang,WU Qi-nan,LI Long-ying,GAO Ai-bin ZHANG Hai-na.The study of the protection of telmisartan on the cognitive function in diabetic rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(15):1514-1516.
高原,肖谦,赵柯湘,吴绮楠,李龙英,高爱滨,张海娜.替米沙坦对糖尿病大鼠认知功能的保护作用[J].陆军军医大学学报(原第三军医大学学报),2007,29(15):1514-1516. DOI：

　GAO Yuan,XIAO Qian,ZHAO Ke-Xiang,WU Qi-nan,LI Long-ying,GAO Ai-bin ZHANG Hai-na.The study of the protection of telmisartan on the cognitive function in diabetic rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(15):1514-1516. DOI：

摘要

目的观察血管紧张素Ⅱ受体拮抗剂替米沙坦对糖尿病大鼠认知功能的保护作用。方法将40只大鼠随机分为正常对照组、糖尿病组、糖尿病+替米沙坦组。建立链脲佐菌素（streptozotocin，STZ)糖尿病大鼠模型，替米沙坦干预12周，Morris水迷宫测试其学习记忆能力，透射电镜观察海马CA1区突触超微结构。结果替米沙坦组与糖尿病组比较，Morris水迷宫测试中潜伏期明显缩短（P0.05），中心区停留时间百分比和通过原平台位置次数增加（P0.05），电镜下海马突触结构明显改善。结论替米沙坦对糖尿病大鼠认知功能有保护作用。

Abstract

Objective To observe the protection of telmisartan on the cognitive function in diabetic rats. Methods 40 rats were randomly divided into the normal control group

diabetic model group and the telmisartan treatment group. Streptozotocin-diabetic rat model was established. The diabetic rats were treated with telmisartan for 12 weeks. Then

the learning and memory abilities of rats were tested with the Morris water maze. Transmission electron microscope was used to observe synapse ultrastructure in hippocampal CA1 area. Results Compared with diabetic model group

the telmisartan treatment group showed a significant decrease in the mean time of escape latencies (P0.05) and an increase in percentage of stay time in the central area and the frequency of passing the original platform position (P0.05). Under electron microscope

hippocampal synapse structure improved. Conclusion It is concluded that telmisartan treatment may protect cognitive function in diabetic rat.

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Related Institution

Department of Immunology, Faculty of Pharmacy and Laboratory Medicine， Army Medical University （Third Military Medical University）

Department of Laboratory Animal Science， College of Basic Medical Sciences, Faculty of Pharmacy and Laboratory Medicine， Army Medical University （Third Military Medical University）

Department of Pharmaceutical Analysis, Faculty of Pharmacy and Laboratory Medicine， Army Medical University （Third Military Medical University）

Department of Otolaryngology Head and Neck Surgery， Chongqing General Hospital （Affiliated Hospital of Chongqing University）

Department of Neurology, Fifth Affiliated Hospital (Zhuhai) of Zunyi Medical University

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