Biodistribution and PET imaging of <sup>18</sup>F-fluoromisonidazole in murine model of lung carcinoma

王钰琦; 郑昕; 周乃康; 张锦明; 柳曦; 张竞

您当前的位置：

首页 >

文章列表页 >

Biodistribution and PET imaging of ¹⁸F-fluoromisonidazole in murine model of lung carcinoma

更新时间：2026-01-09

- Biodistribution and PET imaging of ¹⁸F-fluoromisonidazole in murine model of lung carcinoma
- Journal of Army Medical University Vol. 29, Issue 18, Pages: 1794-1796(2007)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R730.44;R969.1;R981.1
- Published：2007
- 稿件说明：
移动端阅览
王钰琦,郑昕,周乃康,张锦明,柳曦,张竞.18F-FMISO在肺癌模型小鼠体内的生物分布及PET显像研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(18):1794-1796.

　WANG Yu-qi,ZHENG Xin,ZHOU Nai-kang,ZHANG Jin-ming,LIU Xi,ZHANG Jing.Biodistribution and PET imaging of 18F-fluoromisonidazole in murine model of lung carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(18):1794-1796.
王钰琦,郑昕,周乃康,张锦明,柳曦,张竞.18F-FMISO在肺癌模型小鼠体内的生物分布及PET显像研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(18):1794-1796. DOI：

　WANG Yu-qi,ZHENG Xin,ZHOU Nai-kang,ZHANG Jin-ming,LIU Xi,ZHANG Jing.Biodistribution and PET imaging of 18F-fluoromisonidazole in murine model of lung carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(18):1794-1796. DOI：

摘要

目的评价乏氧显像剂

F-硝基咪唑丙醇（

F-FMISO）在肺腺癌动物模型中的诊断价值。方法荷肺腺癌T739小鼠经尾静脉注入

F-FMISO后不同时间（30、60、90、120 min）处死，测量

F-FMISO的生物分布，并行PET显像。对照组小鼠在注入

F-氟脱氧葡萄糖（

F-FDG）后行PET显像。结果荷瘤鼠肿瘤PET显像清晰。生物分布研究表明肿瘤有明显的放射性摄取。在肾脏和肝脏有较高的放射性分布。肿瘤对血和肌肉的T/NT比值均大于2。结论肺部恶性肿瘤组织中

F-FMISO摄取高于正常组织，可通过PET清晰显像，为进一步临床应用于肿瘤的乏氧诊断提供了依据。

Abstract

Objective To evaluate the diagnosis value of a hypoxic contrast

F-fluoromisonidazole (

F-FMISO)

in murine model of pulmonary carcinoma. Methods After the injection of

F-FMISO into the tail

48 T739 mice bearing the pulmonary adenocarcinoma were sacrificed and divided into 4 groups according different killing times (30

90 and 120 min). The biodistribution was measured and PET scanning was performed. Another 8 tumor bearing T734 mice served as control

and PET was carried out after the injection of

F-FDG. Results The tumor PET images with

F-FMISO were clear. Considerable r

adioactive uptake on tumor was observed. Higher radioactivity was found in the kidneys and liver. The T/NT ratios of tumor/muscle and tumor/blood were above 2.0. Conclusion The uptake of

F-FMISO in pulmonary malignant tissues is higher than that in normal tissues

thus the pulmonary neoplasm can be identified accurately with PET imaging. Our preliminary study provides a basis for further clinical hypoxic diagnose of the tumor.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Experimental study on biodistribution and PET imaging of 3’-deoxy-3’-¹⁸F-fluorothymidine in murine models of lung carcinoma and inflammation

Establishment and standardized modeling of lethal shock rat models in high-altitude, high-cold, and high-heat environments

Establishment of a rat model of infrarenal abdominal aortic aneurysm via retroperitoneal approach

Hepatitis B virus X gene inhibits hepatocyte apoptosis in mice via Akt/mTOR pathway

Establishment and evaluation of mouse model of induced membrane by femur bone defect

Related Author

柳曦

周乃康

张锦明

梁朝阳

张竞

郑昕

WU Yue

ZHU Yu

Related Institution

State Key Laboratory of Trauma and Chemical Poisoning， Department of War Trauma， Shock and Blood Transfusion， Daping Hospital， Army Medical University（Third Military Medical University）

Department of Clinical Medicine, North Sichuan Medical College, Nanchong

Department of Cardiovascular Diseases, Affiliated Hospital, North Sichuan Medical College, Nanchong

Department of Tissue and Embryology, Basic Medical College, North Sichuan Medical College, Nanchong

Molecular Medicine and Cancer Research Center, Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Chongqing Medical University

⁰

Biodistribution and PET imaging of 18F-fluoromisonidazole in murine model of lung carcinoma

DOI：

摘要

Abstract

关键词

Keywords

references

Biodistribution and PET imaging of ¹⁸F-fluoromisonidazole in murine model of lung carcinoma