Correlation of COX-2 and VEGF-C expressions in breast carcinoma with lymph node metastasis

李昌秀; 曹友德

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Correlation of COX-2 and VEGF-C expressions in breast carcinoma with lymph node metastasis

更新时间：2026-01-09

- Correlation of COX-2 and VEGF-C expressions in breast carcinoma with lymph node metastasis
- Journal of Army Medical University Vol. 29, Issue 20, Pages: 1964-1967(2007)
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  CLC： R73-37;R730.231;R737.9
- Published：2007
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李昌秀,曹友德.乳腺癌组织COX-2、VEGF-C的表达与淋巴结转移的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(20):1964-1967.

　LI Chang-xiu,CAO You-de.Correlation of COX-2 and VEGF-C expressions in breast carcinoma with lymph node metastasis[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(20):1964-1967.
李昌秀,曹友德.乳腺癌组织COX-2、VEGF-C的表达与淋巴结转移的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(20):1964-1967. DOI：

　LI Chang-xiu,CAO You-de.Correlation of COX-2 and VEGF-C expressions in breast carcinoma with lymph node metastasis[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(20):1964-1967. DOI：

摘要

目的研究COX-2、VEGF-C在乳腺癌组织中的表达及其与淋巴管生成、淋巴结转移间的相关性。方法采用免疫组化学SP法检测46例浸润性导管癌组织中COX-2、VEGF-C的表达，通过淋巴管特异性标记物D2-40记数淋巴管密度（LVD），分析COX-2、VEGF-C的表达与淋巴管生成和淋巴结癌组织转移的相关性。结果 ①乳腺癌组织COX-2、VEGF-C表达阳性率分别为73.91%(34/46)和71.74%(33/46)。②有淋巴结转移组COX-2阳性率为86.48%(32/37）、VEGF-C为81.08%(30/37)，D2-40阳性淋巴管密度为(13.350±3.097)/×200。无淋巴结转移组COX-2为22.22%(2/9)、VEGF-C为33.33%(3/9)、LVD为(9.560±2.031)/×200，转移组中COX-2、VEGF-C的表达及淋巴管密度均明显高于无转移组(P0.01)。③VEGF-C表达与COX-2表达呈正相关（r=0.757

P0.01）

并且COX-2、VEGF-C的表达与LVD也呈正相关(P0.01）。结论 VEGF-C、COX-2在人乳腺癌组织呈高水平表达，其表达与肿瘤淋巴管密度及癌组织淋巴结转移有关；COX-2可能通过诱导VEGF-C表达促进肿瘤淋巴管生成和淋巴结转移。

Abstract

Objective To investigate the expressions of COX-2 and VEGF-C in breast carcinoma and their correlation with lymphangiogenesis and lymph node metastasis. Methods The expressions of COX-2 and VEGF-C and D2-40 were evaluated in 46 cases of breast carcinoma by immunohistochemical staining SP methods. The lymphatic vessels density (LVD) in tumor was counted through the special marker D2-40. Results The positive rate of COX-2 and of VEGF-C was 73.91% (34/46) and 71.74% (33/46) respectively in breast carcinoma tissues. The positive rate of COX-2 and VEGF-C was 86.48% (32/37) and 81.08% (30/37)

and LVD was (13.350±3.097)/×200 in the lymph node metastasis group

while that in non-lymph-node metastasis group was 22.22% (2/9)

33.33% (3/9) and (9.560±2.031)/×200 respectively

with significant difference between the two groups (P0.01). VEGF-C expression was positively correlated with COX-2 expression (r=0.757

P0.01). The expressions of COX-2 and VEGF-C were positively correlated with LVD (P0.01). Conclusion The expressions of COX-2 and VEGF-C were high in breast carcinoma

which were closely related with tumor LVD and lymph node metastasis. A positive correlation was found between the expressions of VEGF-C and COX-2 in breast carcinoma. COX-2 may promote tumor lymphangiogenesis and metastasis of tumor lymph node by inducing VEGF-C expression.

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