Effect of varicocele on expressions of HIF-1α and Bax in germ cells of adolescent  rats

吕天兵; 苟欣; 余周; 吴跃

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Effect of varicocele on expressions of HIF-1α and Bax in germ cells of adolescent rats

更新时间：2026-01-09

- Effect of varicocele on expressions of HIF-1α and Bax in germ cells of adolescent rats
- Journal of Army Medical University Vol. 29, Issue 19, Pages: 1883-1885(2007)
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  CLC： R322.64;R329.26;R697.24
- Published：2007
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吕天兵,苟欣,余周,吴跃.精索静脉曲张对青春期大鼠睾丸生精细胞HIF-1α和Bax表达的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(19):1883-1885.

　LU Tian-bing,GOU Xin,YU Zhou,WU Yue.Effect of varicocele on expressions of HIF-1α and Bax in germ cells of adolescent rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(19):1883-1885.
吕天兵,苟欣,余周,吴跃.精索静脉曲张对青春期大鼠睾丸生精细胞HIF-1α和Bax表达的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(19):1883-1885. DOI：

　LU Tian-bing,GOU Xin,YU Zhou,WU Yue.Effect of varicocele on expressions of HIF-1α and Bax in germ cells of adolescent rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(19):1883-1885. DOI：

摘要

目的研究精索静脉曲张（varicocele

VC）对大鼠睾丸生精细胞低氧诱导因子-1α(hypoxiainducible factor-1α、HIF-1α)和Bax表达的影响，探索精索静脉曲张引起不育的机制。方法采用青春期雄性Wistar大鼠复制左侧精索静脉曲张模型，将25只大鼠分为VC组（n=15）和假手术组(SOG)(n=10)

于术后30 d一并处死，取左侧睾丸，用免疫组化S-P法检测HIF-1α和Bax的表达。结果 HIF-1α和Bax在VC组左侧睾丸组织中的表达均明显高于SOG组(P0.05)，二者呈现一定的相关性(r=0.479 2，P0.05）。结论实验性精索静脉曲张可以改变青春期大鼠睾丸组织生精细胞HIF-1α和Bax的表达。

Abstract

Objective To study the effect of varicocele(VC) on the expressions of hypoxia-inducible factor-1α(HIF-1α) and apoptosis-associated gene Bax in germ cells of adolescent rats

and investigate the mechanism of the infertility resulting from varicocele. Methods The varicocele model was established by partial ligation of the left renal vein in adolescent male Wistar rats. A total of 25 rats were randomly divided into 2 groups

namely varicocele group(n=15) and sham operation group (SOG

n=10). All the animals were killed 30 d after operation. The left testis was collected and the expression of HIF-1α and Bax was detected by immunohistochemical method. Results The expression of HIF-1α and Bax in left testis of varicocele group was significantly higher than that of sham operation group(P0.05) and positive correlation was found between them (r=0.479 2，P0.05）. Conclusion Experimental varicocele can change the expression of factor-1α(HIF-1α) and apoptosis associated gene Bax in germ cells of adolescent rats.

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