Effects of electroshock on interferon gamma receptor expression in hippocampus of depressed rats

李大奇; 况利; 王敏建

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Effects of electroshock on interferon gamma receptor expression in hippocampus of depressed rats

更新时间：2026-01-09

- Effects of electroshock on interferon gamma receptor expression in hippocampus of depressed rats
- Journal of Army Medical University Vol. 29, Issue 15, Pages: 1494-1496(2007)
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  CLC： R454.1;R714.02;R749.4
- Published：2007
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李大奇,况利,王敏建.不同电休克方法对抑郁模型大鼠海马干扰素-γ受体表达的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(15):1494-1496.

　LI Da-qi,KUANG Li,WANG Min-jian.Effects of electroshock on interferon gamma receptor expression in hippocampus of depressed rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(15):1494-1496.
李大奇,况利,王敏建.不同电休克方法对抑郁模型大鼠海马干扰素-γ受体表达的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(15):1494-1496. DOI：

　LI Da-qi,KUANG Li,WANG Min-jian.Effects of electroshock on interferon gamma receptor expression in hippocampus of depressed rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(15):1494-1496. DOI：

摘要

目的观察干扰素-γ受体（IFN-γR）在抑郁模型大鼠海马神经元及胶质细胞中的再生。方法采用慢性轻度不可预见性的应激(chronic unpredicped mild stress

CUMS)和孤养建立大鼠抑郁模型，开场分析（open-field test）进行行为学观察。对模型大鼠行电休克（electro-convulsive treatment

ECT）及丙泊酚无抽搐电休克（modified electric convulsive therapy

MECT）疗法

免疫荧光及原位杂交方法观察海马结构中神经元和胶质细胞上IFN-γR的表达情况。结果应激+ECT组、应激+MECT组与应激+假电击组比较，开场分析、免疫荧光及原位杂交实验均有显著差异。结论 MECT治疗和ECT治疗均能减少抑郁模型大鼠海马神经元及胶质细胞上IFN-γR的表达，细胞因子（cytokine

CK）可能参与抑郁症的病理机制，MECT治疗疗效可能较ECT治疗为优。

Abstract

Objective To observe the expression of interferon gamma receptor on neuron and astrocyte of the hippocampus of depressed rats. Methods The depressed rats were produced by separation raise and unpredictable mild stressors.Their behaviors were evaluated in open-field test. The rats underwent electro-convulsive treatment (ECT) or modified electric convulsive therapy (MECT). The expression of interferon gamma receptor on neuron and astrocyte of the hippocampus was detected by immunofluorescence and in situ hybridization. Results There were significant differences among the stress plus ECT group

the stress plus MECT group

the stress plus sham electroshock group in all the three tests. Conclusion ECT and MECT can both reduce the expression of interferon gamma receptor on neuron and astrocyte of the hippocampus of depressed rats

and MECT shows more stronger therapeutic effect. Cytokine may play an important role in the pathophysiologic mechanism of depression.

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