Effects of MK-801 on rat F-VEPs during the critical period of visual development

翁传煌; 秦伟

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Effects of MK-801 on rat F-VEPs during the critical period of visual development

更新时间：2026-01-09

- Effects of MK-801 on rat F-VEPs during the critical period of visual development
- Journal of Army Medical University Vol. 29, Issue 14, Pages: 1394-1395(2007)
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  CLC： R339.14;R770.43;R777.440.2
- Published：2007
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翁传煌,秦伟.MK-801对视觉发育可塑性关键期内大鼠闪光视觉诱发电位的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(14):1394-1395.

　WENG Chuan-huang,QIN Wei.Effects of MK-801 on rat F-VEPs during the critical period of visual development[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(14):1394-1395.
翁传煌,秦伟.MK-801对视觉发育可塑性关键期内大鼠闪光视觉诱发电位的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(14):1394-1395. DOI：

　WENG Chuan-huang,QIN Wei.Effects of MK-801 on rat F-VEPs during the critical period of visual development[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(14):1394-1395. DOI：

摘要

目的在视觉发育可塑性关键期内，探讨MK-801对大鼠闪光视觉诱发电位（F-VEP）的影响。方法对出生后14 d和28 d正常和MK-801处理的大鼠进行F-VEP检查。结果正常组大鼠生后28 d和14 d相比较，F-VEP主波的潜伏期缩短、振幅增高（P0.05）；MK-801处理大鼠与同天龄正常组大鼠相比较，F-VEP主波的潜伏期较长（P0.05）。结论在视觉发育可塑性关键期内，MK-801影响了大鼠F-VEP的经验依赖性变化。

Abstract

Objective To investigate the effects of MK-801 on the rat F-VEPs during the critical period of visual plasticity. Methods We performed the F-VEPs examination in the normal Long Evans rats and the MK-801 treated rats on their postnatal days 14 and 28. Results After eye-opening

the latency of F-VEP main wave became shorter (P0.05) and the amplitude of F-VEP main wave became longer (P0.05) in the normal rats with age. On postnatal day 28

the MK-801 treated rats had the longer latency than the normal rat. Conclusion During the critical period of visual development

MK-801 delays the maturation of rat F-VEPs.

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