Effect of trimetazidine against the apoptosis of type 2 diabetic rat cardiomyocytes

吴绮楠; 肖谦; 吴平; 李龙英; 高原

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Effect of trimetazidine against the apoptosis of type 2 diabetic rat cardiomyocytes

更新时间：2026-01-09

- Effect of trimetazidine against the apoptosis of type 2 diabetic rat cardiomyocytes
- Journal of Army Medical University Vol. 29, Issue 19, Pages: 1866-1868(2007)
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  CLC： R322.11;R587.1;R972.3
- Published：2007
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吴绮楠,肖谦,吴平,李龙英,高原.曲美他嗪对2型糖尿病大鼠心肌细胞凋亡的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(19):1866-1868.

　WU Qi-nan,XIAO Qian,WU Ping,LI Long-ying,GAO Yuan.Effect of trimetazidine against the apoptosis of type 2 diabetic rat cardiomyocytes[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(19):1866-1868.
吴绮楠,肖谦,吴平,李龙英,高原.曲美他嗪对2型糖尿病大鼠心肌细胞凋亡的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(19):1866-1868. DOI：

　WU Qi-nan,XIAO Qian,WU Ping,LI Long-ying,GAO Yuan.Effect of trimetazidine against the apoptosis of type 2 diabetic rat cardiomyocytes[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(19):1866-1868. DOI：

摘要

目的探讨过氧化物酶体增殖物激活受体α(PPARα)的过度表达和曲美他嗪对2型糖尿病大鼠心肌细胞凋亡的影响。方法将SD大鼠分为3组：正常组（N组）； 2型糖尿病组（D组）；2型糖尿病曲美他嗪组（T组）。饲养16周后，TUNEL法检测各组心肌细胞凋亡，免疫组化法检测各组心肌细胞PPARα蛋白的表达。结果与N组相比，D组大鼠PPARα蛋白的表达增高，心肌细胞凋亡增加(P0.01)；与D组相比，T组PPARα表达减少，心肌凋亡减少(P0.01)。结论 PPARα过度表达与糖尿病心肌细胞凋亡有关，可能参与糖尿病心肌病病程，曲美他嗪可有效逆转这一过程。

Abstract

Objective To investigate the overexpression of peroxisome proliferator activated receptor α (PPARα) and the effect of trimetazidine against the apoptosis of cardiomyocyte in rats with type 2 diabetes. Methods All the rats were divided into 3 groups: group N (control group)

group D (type 2 diabetes group)

and group T (type 2 diabetes treated by trimetazidine). After 16 weeks breeding

apoptosis was detected by TUNEL

and immunohistochemistry staining was used to detected PPARα expression in protein level in cardiomyocytes. Results Much apoptosis was observed and the expression of PPARα was decreased in group D as compared with group N (P0.01). In group T

the apoptosis of cardiomyocytes and the expression of PPARα were decreased distinctly as compared with group D (P0.01). Conclusion The overexpression of PPARα might be involved in the regulation of cardiomyocyte apoptosis，suggesting that it may participate in the development of diabetic cardiomyopathy and trimetazidine can reverse it.

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Related Institution

Department of Pathology， Second Affiliated Hospital， Army Medical University （Third Military Medical University）

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Department of Laboratory Animal Science， College of Basic Medical Sciences, Faculty of Pharmacy and Laboratory Medicine， Army Medical University （Third Military Medical University）

Department of Pharmaceutical Analysis, Faculty of Pharmacy and Laboratory Medicine， Army Medical University （Third Military Medical University）

Department of Orthopedics, Dongnan Hospital

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