Olig expression in rats of experimental allergic encephalomyelitis

余洪俊; 费军; 刘宏亮; 汪琴; 姚忠祥

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Olig expression in rats of experimental allergic encephalomyelitis

更新时间：2026-01-09

- Olig expression in rats of experimental allergic encephalomyelitis
- Journal of Army Medical University Vol. 29, Issue 15, Pages: 1482-1484(2007)
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  CLC： R-332;R394.3;R744.3
- Published：2007
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余洪俊,费军,刘宏亮,汪琴,姚忠祥.实验性变态反应性脑脊髓炎大鼠大脑Olig基因表达的变化规律[J].陆军军医大学学报(原第三军医大学学报),2007,29(15):1482-1484.

　YU Hong-jun,FEI Jun,LIU Hong-liang,WANG Qin,YAO Zhong-xiang.Olig expression in rats of experimental allergic encephalomyelitis[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(15):1482-1484.
余洪俊,费军,刘宏亮,汪琴,姚忠祥.实验性变态反应性脑脊髓炎大鼠大脑Olig基因表达的变化规律[J].陆军军医大学学报(原第三军医大学学报),2007,29(15):1482-1484. DOI：

　YU Hong-jun,FEI Jun,LIU Hong-liang,WANG Qin,YAO Zhong-xiang.Olig expression in rats of experimental allergic encephalomyelitis[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(15):1482-1484. DOI：

摘要

目的研究实验性变态反应性脑脊髓炎（experimental allergic encephalomyelitis

EAE）大鼠大脑Olig1

Olig2和Nkx2.2基因的表达规律。方法采用注射豚鼠脊髓匀浆的方法制作Wistar大鼠EAE模型。实时RT-PCR检测基因表达的相对值。结果正常大鼠大脑Olig1

Olig2和Nkx2.2都低水平表达。EAE大鼠症状发作后第6天，其表达水平达最高峰，与正常组比较，相差显著（P0.05）。三者的变化规律一致。结论 Olig基因表达量的增高程度可能是EAE大鼠髓鞘修复不完全的因素之一。

Abstract

Objective To study the experessions of Olig1

Olig2 and Nkx2.2 in th brain tissues of rats of experimental allergic encephalomyelitis (EAE). Methods The Wistar rats were immunized with guinea pig’s homogenated spinal cord mixed with CFA. The expressions of the three genes were detected by real-time PCR. Results In normal rats

Olig1

Olig2 and Nkx2.2 expressed in low level. On day 6 after onset of the symptoms of EAE

the experessions of Olig1

Olig2 and Nkx2.2 reached the peak value

with significant difference with those of normal rats (P0.05). Conclusion The increasing extent of Olig1

Olig2 and Nkx2.2 is related to incomplete remyelination in EAE.

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