Protective effects of tea polyphenols on polycythemia induced by chronic hypoxia in rats

罗红; 高文祥; 高钰琪; 刘福玉; 李鹏

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Protective effects of tea polyphenols on polycythemia induced by chronic hypoxia in rats

更新时间：2026-01-09

- Protective effects of tea polyphenols on polycythemia induced by chronic hypoxia in rats
- Journal of Army Medical University Vol. 29, Issue 14, Pages: 1381-1383(2007)
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  CLC： R282.71;R364.4;R555.101
- Published：2007
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罗红,高文祥,高钰琪,刘福玉,李鹏.茶多酚预防缺氧大鼠红细胞增多症的实验研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(14):1381-1383.

　LUO Hong,GAO Wen-xiang,GAO Yu-qi,LIU Fu-yu,LI Peng.Protective effects of tea polyphenols on polycythemia induced by chronic hypoxia in rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(14):1381-1383.
罗红,高文祥,高钰琪,刘福玉,李鹏.茶多酚预防缺氧大鼠红细胞增多症的实验研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(14):1381-1383. DOI：

　LUO Hong,GAO Wen-xiang,GAO Yu-qi,LIU Fu-yu,LI Peng.Protective effects of tea polyphenols on polycythemia induced by chronic hypoxia in rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(14):1381-1383. DOI：

摘要

目的探讨茶多酚（tea polyphenols

TP）对缺氧大鼠红细胞增多症的预防作用。方法雄性Wistar大鼠，分为平原组、慢性缺氧组、高剂量TP（20 mg/kg）+慢性缺氧组、低剂量TP（10 mg/kg）+慢性缺氧组。大鼠在5 000 m高原环境模拟舱中，间断缺氧（12 h/d）

每2天1次腹腔注射CoCl

溶液（5.5 mg/kg）以建立红细胞增多症模型。经颈动脉插管取血，然后测定大鼠红细胞数、血红蛋白和红细胞压积，并进行血流变学及动脉血气分析。结果 ①红细胞增多症模型组大鼠的红细胞数、血红蛋白和红细胞压积显著增加，全血黏度等血流变学指标显著上升；②与模型组相比，慢性缺氧大鼠的红细胞数、血红蛋白和红细胞压积值均明显下降，且高剂量TP组较低剂量组显著，但仍高于平原组；同时TP可以改善缺氧大鼠血流变学指标，降低全血黏度及红细胞刚性指数等；但TP对缺氧大鼠的血氧饱和度等血气值没有影响。结论 TP对缺氧大鼠红细胞增多症有一定预防作用，提示TP对高原红细胞增多症可能有类似作用。

Abstract

Objective To observe the protective effects of tea polyphenols (TP) on chronical hypoxia induced polycythemia in rats. Methods Wistar rats were divded into 4 groups:(1) the normoxia group

(2) chronical hypoxia group

(3) low dose TP (10 mg/kg)group

(4) high dose TP (20 mg/kg) group. To establish the model of polycythemia

rats in (2)

(3) and (4) were exposed to intermittent hypoxia

at simulated altitude of 5 000 m 12 h/d for 40 days

and were given CoCl

5.5 mg/kg intraperitoneal administration every other day. At the end of the experiment

RBC

HCT and the value of the bloo

d rheology were detected

and arterial blood gas analysis were also done by the analysator. Results The value of RBC

HB and HCT in TP groups were all decreased significantly

and the effects of 20 mg/kg TP was more significant than that of 10 mg/kg Furthermore

TP also decreased the whole blood viscosity and RBC rigidity index in chronical hypoxia rats

which indicated that TP is good to the the blood rheology in chronical hypoxia rats. However

it wasn’t significant that the effects of TP on the value of arterial blood gas such as SaO

in chronical hypoxia rats(P0.05). Conclusion TP may have protective effects on chronical hypoxia induced polycythemia in rats.

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Related Institution

Institute of Immunology, College of Basic Medical Science，Army Medical University （Third Military Medical University）

Reproductive Medical Center， First Affiliated Hospital, College of Basic Medical Science，Army Medical University （Third Military Medical University）

Department of Ultrasonography, Second Affiliated Hospital， Army Medical University （Third Military Medical University）

Department of Cardiovascular Medicine， First Affiliated Hospital, Second Affiliated Hospital， Army Medical University （Third Military Medical University）

Department of Pathophysiology， Faculty of High Altitude Military Medicine, Second Affiliated Hospital， Army Medical University （Third Military Medical University）

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