Expressions, clinicopathological features and prognostic significance of HIF-1α, JNK1, P-gp, MRP1 and LRP proteins in human gastric carcinoma

杨兆瑞; 吴晴; 陈嘉薇; 李大卫; 李淑霞

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Expressions, clinicopathological features and prognostic significance of HIF-1α, JNK1, P-gp, MRP1 and LRP proteins in human gastric carcinoma

更新时间：2026-01-09

- Expressions, clinicopathological features and prognostic significance of HIF-1α, JNK1, P-gp, MRP1 and LRP proteins in human gastric carcinoma
- Journal of Army Medical University Vol. 29, Issue 18, Pages: 1755-1759(2007)
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  CLC： R730.2;R730.43;R735.2
- Published：2007
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杨兆瑞,吴晴,陈嘉薇,李大卫,李淑霞.HIF-1α、JNK1、P-gp、MRP1和LRP蛋白在胃癌中的表达与临床病理及预后的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(18):1755-1759.

　YANG Zhao-rui,WU Qing,CHEN Jia-wei,LI Da-wei,LI Shu-xia.Expressions, clinicopathological features and prognostic significance of HIF-1α, JNK1, P-gp, MRP1 and LRP proteins in human gastric carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(18):1755-1759.
杨兆瑞,吴晴,陈嘉薇,李大卫,李淑霞.HIF-1α、JNK1、P-gp、MRP1和LRP蛋白在胃癌中的表达与临床病理及预后的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(18):1755-1759. DOI：

　YANG Zhao-rui,WU Qing,CHEN Jia-wei,LI Da-wei,LI Shu-xia.Expressions, clinicopathological features and prognostic significance of HIF-1α, JNK1, P-gp, MRP1 and LRP proteins in human gastric carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(18):1755-1759. DOI：

摘要

目的探讨HIF-1α、JNK1、P-gp、MRP1和LRP蛋白在胃癌中的表达、临床病理关系及预后意义。方法应用组织芯片技术结合免疫组化染色，检测HIF-1α、JNK1、P-gp、MRP1和LRP在135例胃癌及27例正常胃黏膜中的表达。结果 HIF-1α、JNK1、P-gp、MRP1和LRP在胃癌组织中阳性表达率高于正常胃黏膜（P0.05）；TNM分期中的Ⅲ~Ⅳ期组和伴有淋巴结转移组的HIF-1α、P-gp、MRP1、LRP阳性表达率高于相应的Ⅰ~Ⅱ期组和无淋巴结转移组（P0.05）；JNK1的阳性表达与临床病理各参数之间无明显相关。HIF-1α、JNK1、P-gp、MRP1和LRP各指标间存在正相关关系（P0.01），并与生存期密切相关，阳性表达组较之阴性表达组平均生存期缩短（P0.05）。结论 HIF-1α、P-gp、MRP1、LRP阳性表达与胃癌侵袭、转移密切相关；HIF-1α、JNK1、P-gp、MRP1和LRP阳性表达可能具有胃癌预后判断的重要意义。

Abstract

Objective To investigate the expressions

clinical pathological features and prognostic significance of HIF-1α

JNK1 and multidrug resistance proteins: P-gp

MRP1 and LRP in human gastric carcinoma. Methods The tissue microarray technique and immunohistochemical EnVision method were used to detect HIF-1α

JNK1

P-gp

MRP1 and LRP proteins in 135 specimens of gastric carcinoma and 27 gastric mucosa tissues. Results In gastric carcinoma

the positive expression rate of HIF-1α

JNK1

P-gp

MRP1and LRP was higher than that in gastric mucosa tissues (P0.05). The positive expression rate of HIF-1α

P-gp

MRP1 and LRP in the group of Ⅲ-Ⅳ stages (TNM stage) and the group of lymphonode metastasis was higher than that in the group of Ⅰ-Ⅱ states and the group of non-lymphonode metastasis respectively (P0.05). The positive expression of JNK1 protein was not significantly correlated with clinicopathological features. A positive correlation was found between each other in expressions of HIF-1α

JNK1

P-gp

MRP1 and LRP proteins in gastric carcinoma (P0.01). Their expressions were also correlated with survival time. The average survival time of the negative group was longer than that of positive group (P0.05). Conclusion The positive expressions of HIF-1α

P-gp

MRP1 and LRP in gastric carcinoma are significantly correlated with the gastric carcinoma invasion and lymphonode metastasis. The positive expressions of HIF-1α

P-gp

MRP1

LRP and JNK1 proteins may be of predictive value in gastric carcinoma.

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