Ovarian function in rat model of chronic emotional stress

程湘; 徐辉; 艾国平; 粟永萍; 谢荣凯; 陈正琼; 吴家燕

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Ovarian function in rat model of chronic emotional stress

更新时间：2026-01-09

- Ovarian function in rat model of chronic emotional stress
- Journal of Army Medical University Vol. 29, Issue 14, Pages: 1368-1370(2007)
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  CLC： R339.22;R395.1
- Published：2007
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程湘,徐辉,艾国平,粟永萍,谢荣凯,陈正琼,吴家燕.慢性情绪应激对大鼠卵巢功能影响的初步观察[J].陆军军医大学学报(原第三军医大学学报),2007,29(14):1368-1370.

　CHENG Xiang,XU Hui,AI Guo-ping,SU Yong-ping,XIE Rong-kai,CHEN Zheng-qiong,WU Jia-yan.Ovarian function in rat model of chronic emotional stress[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(14):1368-1370.
程湘,徐辉,艾国平,粟永萍,谢荣凯,陈正琼,吴家燕.慢性情绪应激对大鼠卵巢功能影响的初步观察[J].陆军军医大学学报(原第三军医大学学报),2007,29(14):1368-1370. DOI：

　CHENG Xiang,XU Hui,AI Guo-ping,SU Yong-ping,XIE Rong-kai,CHEN Zheng-qiong,WU Jia-yan.Ovarian function in rat model of chronic emotional stress[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(14):1368-1370. DOI：

摘要

目的观察慢性情绪应激对大鼠卵巢功能的影响。方法以不确定性空瓶饮水刺激作为情绪应激源，考察20 d的慢性情绪应激对雌性大鼠行为、脾脏指数、动情周期和血中FSH、LH、E

和P含量的影响。结果慢性情绪应激明显诱发雌性大鼠的攻击行为，增加脾脏指数，差异非常显著（P0.01）。慢性情绪应激延长雌性大鼠的动情周期，差异非常显著（P0.01），但对卵巢指数没有显著影响（P0.05）。慢性情绪应激减少雌性大鼠血中E

含量，差异非常显著（P0.01）

而对血中P含量没有显著影响（P0.05）；同时慢性情绪应激后大鼠血中FSH和LH含量下降，差异非常显著（P0.01）。结论慢性情绪应激影响大鼠卵巢分泌功能，该模型可用于情绪应激对生殖内分泌影响的研究。

Abstract

Objective To observe the effect of chronic emotional stress on ovarian function in rats. Methods The uncertain empty bottle stress was used as a source of emotional stress

and 20 day stress was carried out in 20 female SD rats aged 3 months. Another 20 rats were used as controls. The behavior changes and estrous cycle were observed. The serum levels of FSH

and P were determined. Results The chronic emotional stress could increase attacking behavior and splenic index significantly (P0.01)

and prolong the estrous cycle significantly (P0.01)

but had no influence on ovarian index (P0.05). It could decrease serum FSH

LH and E

levels significantly (P0.01)

but had no effect on P levels (P0.05). Concl

usion The chronic emotional stress can influence the ovarian endocrine secretion in rats. This model may be used to study the influence of chronic emotional stress on generative endocrine secretion.

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