Objective    To study the expression of interferon-induced protein with tetratricopetide repeats 1 (IFIT1）in various organs of mice and detect the effect of cervical sympathetic block (SB) on hepatic IFIT1 during the early stage in burned mice.       Methods    Fifty male C57/129 mice inflicted with 15%-20% TBSA full thickness burn injury were divided randomly into control group (untreated by SB) and SB group(treated immediately by SB). Hepatic tissue was taken before burn injury and at 1st h

6th h

12th h

and 24th h after burn injury. The protein expression level of IFIT1 was measured by Western blot.  RNA was extracted from the heart

liver

spleen

lung

kidney

small intestine

lymphocyte and skeletal muscle of normal mice; then the RNA expression level of IFIT1 was detected by RT-PCR.       Results    The RNA expression of IFIT1 was detected in heart

liver

spleen

lung

kidney

small intestine

lymphocyte and skeletal muscle of normal mice

but there was difference in various organs. The result of Western blot displayed that the protein expression level of IFIT1 in control group increased significantly (P0.01). The level of IFIT1 in SB group was decreased significantly at different time points after burn injury as compared with the control group (P0.01).        Conclusion    IFIT1 is generally expressed in various organs of mice. SB could enhance the function of GR by exerting suppression on IFIT1 level.