Pharmacokinetics of VEGF125-136 in rabbits by radionuclide tracing

黄定德; 罗朝学; 刘广元; 郑磊; 陈杰; 李前伟; 程绍钧

您当前的位置：

首页 >

文章列表页 >

Pharmacokinetics of VEGF125-136 in rabbits by radionuclide tracing

更新时间：2026-01-09

- Pharmacokinetics of VEGF125-136 in rabbits by radionuclide tracing
- Journal of Army Medical University Vol. 29, Issue 18, Pages: 1746-1748(2007)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R817;R969.1;R977.6
- Published：2007
- 稿件说明：
移动端阅览
黄定德,罗朝学,刘广元,郑磊,陈杰,李前伟,程绍钧.放射性核素示踪法对多肽VEGF125-136在家兔体内的药代动力学研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(18):1746-1748.

　HUANG Ding-de,LUO Chang-xue,LIU Guao-yuan,ZHENG Lei,CHEN Jie,LI Qian-wei,CHEN Shao-jun.Pharmacokinetics of VEGF125-136 in rabbits by radionuclide tracing[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(18):1746-1748.
黄定德,罗朝学,刘广元,郑磊,陈杰,李前伟,程绍钧.放射性核素示踪法对多肽VEGF125-136在家兔体内的药代动力学研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(18):1746-1748. DOI：

　HUANG Ding-de,LUO Chang-xue,LIU Guao-yuan,ZHENG Lei,CHEN Jie,LI Qian-wei,CHEN Shao-jun.Pharmacokinetics of VEGF125-136 in rabbits by radionuclide tracing[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(18):1746-1748. DOI：

摘要

目的探讨VEGF125-136在家兔体内的药代动力学。方法采用放射性核素

对VEGF125-136进行间接标记。测定6 只家兔静脉注射37 MBq

V-EGF125-136后不同时间血浆中药物的放射性浓度，用DAS软件编制放射性浓度时间曲线，并计算药代动力学参数。结果

-VEGF125-136的放射化学纯度大于97%，

-VEGF125-136在家兔体内的代谢符合三室模型，快分布相半衰期（t

1/2α

）为（5.327±2.351） min，慢分布相半衰期（t

1/2β

）为（26.446±6.502） min，消除相半衰期（t

1/2γ

）为（304.41±216.811） min，转运速率常数K

、K

及K

分别为（0.047±0.034）、（40.65±68.54）、（0.111±0.058）、（0.111±0.058）min

-1

及（0.002±0.004） min

-1

，清除率（CL）为（4.00±1.00） ml/min。结论 VEGF125-136在家兔体内的药代动力学符合三室模型，且血液清除快而周边血管丰富的组织停留时间相对较长。

Abstract

Objective To investigate the pharmacokinetics of a 12-amino-acid residue peptide of vascular endothelial growth factor (VEGF

125-136) in rabbits. Methods VEGF125-136 was indirectly labeled with

. After a single dose of 37 MBq of

-VEGF125-136 was injected intravenously in 6 rabbits

the radioactive concentration

s at different sampling times were determined. Then the plasma radioactive concentration-time curve was drawn and pharmacokinetics parameters were calculated with DAS computer program. Results The radiochemistry purity of

-VEGF125-136 was more than 97%

the radioactive concentration-time curve of

-VEGF125-136 was fitted to a three-compartment model with the main pharmacokinetic parameters as follows: t

1/2α

1/2β

and t

1/2γ

were (5.327±2.351)

(26.446±6.502) and (304.41±216.811) min respectively. CL

and K

were (4.00±1.00) ml/min

(0.047±0.034) min

-1

(40.65±68.54) min

-1

(0.111±0.058) min

-1

(0.111±0.058) min

-1

and (0.002±0.004) min

-1

respectively. Conclusion The pharmacokinetics is fitted to three compartment model in rabbits. VEGF125-136 can be cleared quickly from blood and its detention time in target tissue is long.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Pharmacokinetic study of ranolazine in Chinese healthy volunteers

Oxymatrine combined with cisplatin enhances expression of vascular endothelial growth factor and CD31 in subcutaneous xenografts of human hepatocellular carcinoma in nude mice

Determination of ginsenoside Rg3 in rat plasma using high-performance liquid chromatography-tandem mass spectrometry

Influence of SLCO1B1 gene T521C polymorphism on pharmacokinetics of HMG-CoA reductase inhibitors: a meta-analysis

Pharmacokinetics and pharmacodynamics of injectable dex-rabrazole for healthy people

Related Author

Mingjie YU

Rongfeng XIANG

Lirong XIONG

Xiaoyu LI

Qing DAI

Yongchuan CHEN

Jing HU

Zansong HUANG

Related Institution

Department of Pharmacy, First Affiliated Hospital, Army Medical University (Third Military Medical University)

Department of Pharmacy, Handan Branch of No. 980 Hospital of PLA

Department of Gastroenterology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Zhuang Autonomous Region

Institute of Gastroenterology, Southwest Hospital, Third Military Medical University

Department of Gastroenterology， Second Affiliated Hospital， Army Medical University （Third Military Medical University）

⁰