Free vascular endothelial growth factor and its soluble receptor in peritoneal fluid from endometriosis patients

史淑红; 李佃贵; 马秀菊

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Free vascular endothelial growth factor and its soluble receptor in peritoneal fluid from endometriosis patients

更新时间：2026-01-09

- Free vascular endothelial growth factor and its soluble receptor in peritoneal fluid from endometriosis patients
- Journal of Army Medical University Vol. 29, Issue 10, Pages: 976-978(2007)
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  CLC： R392.11;R446.19;R711.71
- Published：2007
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史淑红,李佃贵,马秀菊.子宫内膜异位症患者腹腔液中血管内皮生长因子及其可溶性受体的测定[J].陆军军医大学学报(原第三军医大学学报),2007,29(10):976-978.

　SHI Shu-hong,LI Dian-gui,MA Xiu-ju.Free vascular endothelial growth factor and its soluble receptor in peritoneal fluid from endometriosis patients[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(10):976-978.
史淑红,李佃贵,马秀菊.子宫内膜异位症患者腹腔液中血管内皮生长因子及其可溶性受体的测定[J].陆军军医大学学报(原第三军医大学学报),2007,29(10):976-978. DOI：

　SHI Shu-hong,LI Dian-gui,MA Xiu-ju.Free vascular endothelial growth factor and its soluble receptor in peritoneal fluid from endometriosis patients[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(10):976-978. DOI：

摘要

目的探讨子宫内膜异位症患者血管内皮生长因子可溶性受体1（soluble receptor 1 of vascular endothelial growth factor

s-VEGFR-1/soluble fms-like tyrosine kinase

SFlt-1）调节血管内皮生长因子（vascular endothelial growth factor

VEGF）活动的机制。方法采用酶联免疫吸附法（ELISA），对28例子宫内膜异位症患者的腹腔液中游离的VEGF及s-VEGFR-1进行测定并计算活性指数（VEGF/s-VEGFR-1）。以10例正常生育期妇女为对照。结果 ①子宫内膜异位症组VEGF水平明显高于对照组﹙P0.01)。Ⅲ~Ⅳ期高于Ⅰ~Ⅱ期﹙P0.05)。②子宫内膜异位症组s-VEGFR-1水平也明显高于对照组﹙P0.01)。Ⅰ~Ⅱ期与Ⅲ~Ⅳ期之间无显著差异（P0.05）。③对照组、Ⅰ~Ⅱ期和Ⅲ~Ⅳ期VEGF活性指数分别为0.310、0.276和0.273。④子宫内膜异位症组增生期VEGF及s-VEGFR-1水平均明显高于分泌期﹙P0.01)。⑤子宫内膜异位症组增生期VEGF活性指数低于分泌期。结论 VEGF在子宫内膜异位症的血管发生中有重要作用，但采用VEGF活性指数能更好地了解VEGF在病理学方面的作用。s-VEGFR-1对VEGF有下调作用。

Abstract

Objective To better understand the regulation of the soluble receptor of vascular endothelial growth factor (VEGF)

s-VEGFR-1 (or soluble fms-like tyrosine kinase

SFlt-1)

in angiogenetic process in endometriosis. Methods Levels of free VEGF and s-VEGFR-1 were measured by enzyme-linked immunosorbent assay (ELISA) in peritoneal fluid from 28 subjects with surgically confirmed endometriosis

and 10 controls with no clinical evidence of the disease and other diseases. Meanwhile

we calculated a VEGF activity index by means of the ratio VEGF/s-VEGFR-1. Results We found higher VEGF concentration in endometriotic lesions than controls (P0.01) and VEGF concentration in stage Ⅲ-Ⅳ was higher than in stage Ⅰ-Ⅱ (P0.05). S-VEGFR-1 concentration followed a similar pattern with VEGF (P0.01)

but no statistically significant difference was found between stage Ⅲ-Ⅳ and stage Ⅰ-Ⅱ (P0.05). VEGF activity index in controls

stage Ⅰ-Ⅱ and stages Ⅲ-Ⅳ of endometriosis was 0.310

0.276 and 0.273

respectively. VEGF and s-VEGFR-1 concentration were also higher in proliferative phase than in secretory phase in endometriotic lesions (P0.01). VEGF activity index in proliferative phase was lower than in secretory phase of endometriosis. Conclusion VEGF certainly plays an important role in endometriosis and its progression. However

the activity index may be better to investigate the real role of VEGF in the pathology. s-VEGFR-1 can down-regulate VEGF activity.

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