Effect of neoadjuvant chemotherapy on Survivin, p53 expression in breast cancer

凡庆东; 姜军; 杨新华; 范林军; 钟玲

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Effect of neoadjuvant chemotherapy on Survivin, p53 expression in breast cancer

更新时间：2026-01-09

- Effect of neoadjuvant chemotherapy on Survivin, p53 expression in breast cancer
- Journal of Army Medical University Vol. 29, Issue 11, Pages: 1096-1098(2007)
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  CLC： R730.23;R730.53;R737.9
- Published：2007
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凡庆东,姜军,杨新华,范林军,钟玲.新辅助化疗对乳腺癌Survivin、p53表达影响及意义[J].陆军军医大学学报(原第三军医大学学报),2007,29(11):1096-1098.

　FAN Qing-dong,JIANG Jun,YANG Xin-hua,FAN Lin-jun,ZHONG Ling.Effect of neoadjuvant chemotherapy on Survivin, p53 expression in breast cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1096-1098.
凡庆东,姜军,杨新华,范林军,钟玲.新辅助化疗对乳腺癌Survivin、p53表达影响及意义[J].陆军军医大学学报(原第三军医大学学报),2007,29(11):1096-1098. DOI：

　FAN Qing-dong,JIANG Jun,YANG Xin-hua,FAN Lin-jun,ZHONG Ling.Effect of neoadjuvant chemotherapy on Survivin, p53 expression in breast cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1096-1098. DOI：

摘要

目的探讨乳腺癌新辅助化疗前后Survivin、 p53蛋白表达变化

分析表达变化与临床疗效的关系。方法 51例可手术女性乳腺癌患者采用TE方案新辅助化疗

免疫组化S-P法检测新辅助化疗前后Survivin、p53蛋白表达情况。结果 ① 化疗后Survivin表达明显下降，p53表达未见显著性变化。②化疗后Survivin表达降低，化疗有效率高，Survivin的表达升高，化疗有效率低，两者有显著性差异（P0.05），p53表达变化之间化疗有效率无显著性差异（P0.05)。结论 Survivin在新辅助化疗后表达显著降低

Survivin可能是TE方案新辅助化疗的一个靶点。

Abstract

Objective To study the expression changes of Survivin

p53 in breast cancer after neoadjuvant chemotherapy and analyze the relationship between expression changes and efficiency of neoadjuvant chemotherapy. Methods The expressions of Survivin

p53 were examined by immunohistochemical assay in breast tissue samples from 51 operable breast cancer patients before and after neoadjuvant chemotherapy of TE (Taxinol and Epirubicin) regimen. Results After neoadjuvant chemotherapy

the expression of Survivin decreased significantly (P0.05)

but p53 showed no significant changes. Altered expression of Survivin was correlated with efficiency of neoadjuvant chemotherapy (P0.05). Conclusion After neoadjuvant chemotherapy of TE regimen

the expression of Survivin decreased. The gene Survivin may be a target gene in this regimen.

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