Expression and significance of estrogen receptor isoforms in different breast tissues

徐鹰妮; 姜军; 程鸿; 凡庆东; 谢竞; 周艳; 唐鹏

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Expression and significance of estrogen receptor isoforms in different breast tissues

更新时间：2026-01-09

- Expression and significance of estrogen receptor isoforms in different breast tissues
- Journal of Army Medical University Vol. 29, Issue 11, Pages: 1093-1095(2007)
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  CLC： R347.913;R392-33;R737.9
- Published：2007
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徐鹰妮,姜军,程鸿,凡庆东,谢竞,周艳,唐鹏.ERα和ERβ在不同类型乳腺组织的表达及其意义[J].陆军军医大学学报(原第三军医大学学报),2007,29(11):1093-1095.

　XU Ying-ni,JIANG Jun,CHENG Hong,FAN Qing-dong,XIE Jing,ZHOU Yan,TANG Peng.Expression and significance of estrogen receptor isoforms in different breast tissues[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1093-1095.
徐鹰妮,姜军,程鸿,凡庆东,谢竞,周艳,唐鹏.ERα和ERβ在不同类型乳腺组织的表达及其意义[J].陆军军医大学学报(原第三军医大学学报),2007,29(11):1093-1095. DOI：

　XU Ying-ni,JIANG Jun,CHENG Hong,FAN Qing-dong,XIE Jing,ZHOU Yan,TANG Peng.Expression and significance of estrogen receptor isoforms in different breast tissues[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1093-1095. DOI：

摘要

目的探讨乳腺正常组织经良性病变至癌变过程中雌激素受体（ER）亚型ERα和ERβ表达的变化及其意义。方法用免疫组化EnVision两步法检测94例女性浸润性乳腺癌、乳腺原位癌、良性病变和正常乳腺组织的雌激素受体亚型表达。结果 ERα局限表达于乳腺腺上皮细胞核，相反ERβ广泛表达于腺上皮细胞、间质细胞、肌上皮细胞、内皮细胞和淋巴细胞，且多见细胞质、细胞核同时表达。正常乳腺组织和乳腺良性病变组织的上皮细胞ERα、ERβ染色结果相似；浸润性乳腺癌和乳腺原位癌的ERα表达明显降低；浸润性乳腺癌ERβ表达明显降低；浸润性乳腺癌和乳腺原位癌ERα、ERβ的共表达明显降低。结论 ERβ广泛表达于间质细胞可能与其旁分泌作用有关。ERβ可能与乳腺癌的发生有关，而在乳腺癌中ERβ可能减弱对ERα的调节作用。

Abstract

Objective To investigate the estrogen receptor (ER) isoforms ERα and ERβ expressions and their relationship with clinicopathological parameters in normal breast tissue

benign breast diseases

breast cancer in situ and invasive breast cancer tissue. Methods Breast tissue samples were obtained

including normal breast tissue (14 cases)

benign breast diseases (35 cases)

breast cancer in situ (8 cases) and invasive breast cancer (37 cases). Immunohistochemistry was used to measure the expressions of ERα and ERβ in the breast tissues. Results The profiles of the ERα and ERβ expressions in normal tissues and the tissues of benign breast diseases were similar. Compared with normal breast tissues and benign breast diseases

ERα protein level was down-regulated in the tissues of breast cancer in situ and invasive breast cancer significantly (P0.01); ERβ protein level was down-regulated in the tissues of invasive breast cancer notably (P0.01); The coexpression of ERα and ERβ was decreased in the tissues of breast cancer in situ and invasive breast cancer remarkably (P0.01). Conclusion ERβ may play a role in the human breast cancer probably by modulating ERα activity.

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