Association of ERβ expression with the clinical pathologic indexes and prognostic biomarkers of breast cancer

周艳; 张毅; 梁燕; 姜军

您当前的位置：

首页 >

文章列表页 >

Association of ERβ expression with the clinical pathologic indexes and prognostic biomarkers of breast cancer

更新时间：2026-01-09

- Association of ERβ expression with the clinical pathologic indexes and prognostic biomarkers of breast cancer
- Journal of Army Medical University Vol. 29, Issue 11, Pages: 1090-1092(2007)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R392.1;R730.23;R737.9
- Published：2007
- 稿件说明：
移动端阅览
周艳,张毅,梁燕,姜军.乳腺癌雌激素受体β表达与临床病理及预后标志物的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(11):1090-1092.

　ZHOU Yan,ZHANG Yi,LIANG Yan,JIANG Jun.Association of ERβ expression with the clinical pathologic indexes and prognostic biomarkers of breast cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1090-1092.
周艳,张毅,梁燕,姜军.乳腺癌雌激素受体β表达与临床病理及预后标志物的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(11):1090-1092. DOI：

　ZHOU Yan,ZHANG Yi,LIANG Yan,JIANG Jun.Association of ERβ expression with the clinical pathologic indexes and prognostic biomarkers of breast cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1090-1092. DOI：

摘要

目的探讨雌激素受体亚型ERβ在乳腺组织中的表达及其与ERα、PR、其他生物学预后标志物以及和临床病理参数的关系。方法采用组织芯片和免疫组化技术，比较109 例原发性乳腺癌患者中ERβ表达与ERα、PR、其他生物学预后标志物以及和临床病理参数的关系。结果 ERβ蛋白在良性上皮细胞和间质细胞中均有表达，不同乳腺癌组织类型中59％ERβ表达阳性，其中45 ％病例ERβ和ERα同时表达。统计学分析结果显示

ERβ阳性表达组中，HER-2/neu和p53蛋白表达率显著高于ERβ阴性组，而ERβ表达与否同各临床指标间无显著性差异。结论 ERβ可能是乳腺癌重要的预后指标及治疗靶点。

Abstract

Objective To study the association of ERβ expression with the expression of hormonal receptor and prognostic biomarkers. Methods The expressions of ERβ

ERα

Ki-67

HER-2/neu and p53 were detected in tissue samples from 109 breast cancer patients by immunohistochemistry on tissue microarray slides. The histologic grade

tumor size and lymph node metastasis status of 109 cases of breast cancer were recorded and served as comparison indexes. Results ERβ was expressed in benign epithelium and stroma cells

and breast cancer cells in 59% breast cancer tissues of different histologic types. ERβ was coexpressed with ERα in 45% breast cancer tissues. ERβ expression was found a statistically significant association with HER-2/neu (P0.05) and p53 (P0.05). No statistically significant association was seen between ERβ expression and histologic grade

tumor size and lymph node metastasis. Conclusion ERβ may be an important prognostic marker and therapeutic target in breast cancer.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

A novel estrogen receptor expression stratification (low/moderate/high) based on Chinese population provides more accurate prognosis prediction for HR⁺/HER2^- early breast cancer patients

Immunosuppressive microenvironment of TGIF1-overexpressing gastric cancers and its clinical significance

Impact of molecular heterogeneity of NPM1 mutations on prognosis of acute myeloid leukemia: a clinical report of 86 cases

Association of 5-factor modified frailty index and controlling nutritional status score with overall survival in patients with unresectable hepatocellular carcinoma undergoing interventional therapy

Construction and validation of prediction model for cervical cancer recurrence based on systemic inflammation response index and clinicopathological parameters

Related Author

WANG Chengfang

ZHOU Yuqin

ZHANG Yanling

QI Xiaowei

ZHANG Yi

TONG Huyun

CHEN Xu

ZHANG Wenjie

Related Institution

Department of Breast and Thyroid Surgery， First Affiliated Hospital， Army Medical University （Third Military Medical University）

Department of Gastroenterology， Chongqing Hechuan District People’s Hospital

School of Medicine， Chongqing University

Chongqing Key Laboratory of Precision Prevention and Treatment for Digestive System Tumors， Department of Gastroenterology， Army Medical Center of PLA/Daping Hospital of Third Military Medical University

Department of Hematology, the First Hospital of Lanzhou University

⁰