Objective     To evaluate the safety and efficiency in pain control after laparoscopic cholecystectomy of Fentaynyl transdermal system combined with local infiltration of ropivacaine.      Methods     A hundred and twenty patients ready for selective laparoscopic cholecystectomy were randomly divided into three groups. Ropivacaine group underwent cholecyst bed surface insufflation and local incision infiltration with 0.5% ropivacaine before incision suture; Fentanyl transdermal system group applied Fentanyl transdermal system onto their chests immediately after entering operation room; Combination group underwent both procedures of ropivacaine group and Fentanyl transderma

l system group. All patients experienced general anesthesia with fentanyl-propofol. SPO

2

RR

ECG and blood pressure were monitored continuously after surgery. VAS score and Ramsay score were evaluated. The incidence of nausea

vomiting

pruritus and vertigo was observed.       Results     The analgesic effect was satisfactory in ropivacaine group in postoperative 6 h

in Fentanyl transdermal system group in postoperative 6-48 h

and in postoperative 48 h in combination group. The evidence of respiratory depression was found in no patients. There was no difference among three groups in the incidence of nausea and vomiting. Incidence of pruritus and vertigo in Fentanyl transdermal system group and combination group was higher than ropivacaine group

but without statistical difference (P0.05).       Conclusion     Combination of Fentanyl transdermal system and local infiltration of ropivacaine is safe and efficient in analgesia after laparoscopic cholecystectomy.