Expressions of estrogen receptor and progesterone receptor in elderly breast cancer patients and its relationship with clinical pathology

张毅; 姜军; 杨新华; 封传悦

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Expressions of estrogen receptor and progesterone receptor in elderly breast cancer patients and its relationship with clinical pathology

更新时间：2026-01-09

- Expressions of estrogen receptor and progesterone receptor in elderly breast cancer patients and its relationship with clinical pathology
- Journal of Army Medical University Vol. 29, Issue 5, Pages: 454-456(2007)
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  CLC： R730.2;R737.9
- Published：2007
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张毅,姜军,杨新华,封传悦.老年乳腺癌ER、PR表达及其与临床病理的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(05):454-456.

　ZHANG Yi,JIANG Jun,YANG Xin-hua,FENG Chuan-yue.Expressions of estrogen receptor and progesterone receptor in elderly breast cancer patients and its relationship with clinical pathology[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(05):454-456.
张毅,姜军,杨新华,封传悦.老年乳腺癌ER、PR表达及其与临床病理的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(05):454-456. DOI：

　ZHANG Yi,JIANG Jun,YANG Xin-hua,FENG Chuan-yue.Expressions of estrogen receptor and progesterone receptor in elderly breast cancer patients and its relationship with clinical pathology[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(05):454-456. DOI：

摘要

目的探讨老年患者乳腺癌雌激素受体（estrogen receptor， ER）、孕激素受体（progesterone receptor， PR）表达情况，以及与临床特点和病理学特点的关系。方法回顾性分析本院1995-2004年110例老年乳腺癌（年龄在60岁以上）ER、PR表达情况、病理学特点。选取同期30~59岁非老年妇女乳腺癌110例进行对照分析。结果老年乳腺癌与非老年乳腺癌病理组织学类型相似，但在老年组一些低恶性程度特殊类型癌更为多见。老年乳腺癌ER、PR较非老年乳腺癌有较高的表达，但与临床病理分期无关；腋淋巴结转移在0~3个与4个以上组比较ER、PR有较高的表达。结论老年乳腺癌与非老年乳腺癌病理组织学类型相似，老年乳腺癌有较高的ER、PR表达，同时ER、PR表达与腋淋巴结转移率有关。

Abstract

Objective To study the expressions of estrogen receptor (ER) and progesterone receptor (PR) in elderly patients with breast cancer

and the correlation between their expressions and clinicopathological characteristics. Methods The expressions of ER and PR in 110 elderly patients with breast cancer (over 60 years old) from 1995 to 2004 were detected

and their clinical and pathological features were analyzed retrospectively. Another 110 patients aging 30 to 59 years with breast cancer served as control. Results Breast cancer in aged and non-elderly group had similar pathohistological types

but the aged had more tumors with low-grade malignant types. ER and PR were found to be over-expressed in elderly patients but not in the control. No obvious correlation was seen with clinical pathological stages. The expression levels of ER and PR in 0-3 positive nodes group was higher than ≥4 positive nodes group. Conclusion Elderly patients and non-elderly patients have similar pathohistological types of breast cancer. The former have higher expressions of ER and PR

and their expressions are associated with axillary lymph node status.

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