Role of losartan in AT2-R mediated renal protective effects in renovascular hypertension rat

吕慈; 何凤慈

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Role of losartan in AT2-R mediated renal protective effects in renovascular hypertension rat

更新时间：2026-01-09

- Role of losartan in AT2-R mediated renal protective effects in renovascular hypertension rat
- Journal of Army Medical University Vol. 29, Issue 10, Pages: 941-944(2007)
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  CLC： R334.1;R544.14;R972.4
- Published：2007
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吕慈,何凤慈.氯沙坦在AT2-R介导的肾血管性高血压大鼠肾脏保护功能中的作用[J].陆军军医大学学报(原第三军医大学学报),2007,29(10):941-944.

　LU Ci,HE Feng-ci.Role of losartan in AT2-R mediated renal protective effects in renovascular hypertension rat[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(10):941-944.
吕慈,何凤慈.氯沙坦在AT2-R介导的肾血管性高血压大鼠肾脏保护功能中的作用[J].陆军军医大学学报(原第三军医大学学报),2007,29(10):941-944. DOI：

　LU Ci,HE Feng-ci.Role of losartan in AT2-R mediated renal protective effects in renovascular hypertension rat[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(10):941-944. DOI：

摘要

目的研究在肾血管性高血压的病理条件下氯沙坦对血管紧张素Ⅱ-2型受体（angiotensin Ⅱ type-2 receptors

AT2-R）介导的大鼠肾脏保护功能中的调节作用，并探讨其相关机制。方法雄性SD大鼠采用Goldblatt 方法复制2肾1夹实验性肾血管性高血压模型，分为假手术组和手术组，分别给予低、中、高剂量的氯沙坦处理。用药6周后检测肾脏功能，观察肾脏AT2-R表达

测定血浆和肾脏组织中血管紧张素Ⅱ(angiotensin Ⅱ

AngⅡ)的含量变化。结果在肾血管性高血压大鼠的非缺血肾脏AT2-R表达上调(P0.05)，氯沙坦不仅可升高血浆和肾脏中的AngⅡ含量(P0.05

P0.05)

还可促进高血压大鼠的尿钠排泄，保护肾脏功能，并且对肾脏AT2-R的表达有上调作用(P0.05)。结论氯沙坦通过上调肾脏的AT2-R，介导促尿钠排泄效应，对肾血管性高血压大鼠肾脏起保护作用。

Abstract

Objective To investigate the role of losartan in AT2-R mediated renal protective effects in renovascular hypertension rat. Methods Male SD rats were divided into sham group and renovascular hypertension group in which Goldblatt methods were performed. The two groups were intragastically administered with losartan (respectively 0

30 mg·kg

-1

·d

-1

) for 6 weeks. Then renal function was measured

the AT2-R expression in the non-ischemic kidney and the AngⅡ contents in non-ischemic kidney and plasma were determined. Results In renovascular hypertension rats

especially in the contralateral

non-ischemic

kidney

the expression of AT2-R protein were up-regulated. Losartan increased the AngⅡ contents in non-ischemic kidney and plasma

mediated the natriuretic/diuretic effect and renal protective effect in renovascular hypertension rat and increased the expression of renal AT2-R. Conclusion In renovascular hypertension rat

losartan mediates renal natriuretic/diuretic effect and protects renal function through up-regulating AT2-R in kidney.

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