Objective     To investigate the clinical characteristics

diagnosis and treatment of invasive pituitary adenoma.      Methods     The clinical presentations

imaging studies and surgical outcomes in 62 patients with invasive pituitary adenomas and 78 patients with noninvasive pituitary adenomas were analyzed retrospectively.      Results     Invasive pituitary adenomas were more common in patients with macroadenomas than those with microadenomas (P0.01). The occurrence of  pituitary apoplexy was higher in invasion pituitary adenomas patients than those non-invasion (P0.01). The rate of total tumor resection was lower and the rate of  postoperative  recurrence was higher in patients with invasive tumors than those with noninvasive tumors (P0.05

0.01).      Conclusion     The diagnosis of invasive pituitary adenomas should be made according to preoperative radiological signs

surgical findings and postoperative pathological examinations. Tumor resection is usually partial

adjuvant treatment (radiotherapy or medication) is often necessary in invasive pituitary adenoma patients.