Preparation of isosorbide-5-mononitrate pellets by extrusion/spheronization and study on its properties

刘耀; 刘松青; 戴青; 胡婧; 来小丹

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Preparation of isosorbide-5-mononitrate pellets by extrusion/spheronization and study on its properties

更新时间：2026-01-09

- Preparation of isosorbide-5-mononitrate pellets by extrusion/spheronization and study on its properties
- Journal of Army Medical University Vol. 29, Issue 11, Pages: 1069-1071(2007)
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  CLC： R943;R944.2;R972.4
- Published：2007
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刘耀,刘松青,戴青,胡婧,来小丹.挤出滚圆法制备单硝酸异山梨酯微丸及其性质考察[J].陆军军医大学学报(原第三军医大学学报),2007,29(11):1069-1071.

　LIU Yao,LIU Song-qing,DAI Qing,HU Jing,LAI Xiao-dan.Preparation of isosorbide-5-mononitrate pellets by extrusion/spheronization and study on its properties[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1069-1071.
刘耀,刘松青,戴青,胡婧,来小丹.挤出滚圆法制备单硝酸异山梨酯微丸及其性质考察[J].陆军军医大学学报(原第三军医大学学报),2007,29(11):1069-1071. DOI：

　LIU Yao,LIU Song-qing,DAI Qing,HU Jing,LAI Xiao-dan.Preparation of isosorbide-5-mononitrate pellets by extrusion/spheronization and study on its properties[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1069-1071. DOI：

摘要

目的应用挤出滚圆法制备单硝酸异山梨酯微丸并考虑制备过程中各因素的影响。方法利用挤出滚圆法制备微丸，采用L

)正交设计试验优化了工艺条件，并考察了微丸的粉体学性质及体外溶出度。结果制得的单硝酸异山梨酯微丸圆整度好，大小均匀。体外溶出度在达到95％以上。结论制备的微丸符合药用要求，制备工艺简单易行，适合工业化生产。

Abstract

Objective To prepare isosorbide mononitrate pellets by extrusion/spheronization and determine the pellets’ properties． Methods Isosorbide mononitrate pellets were prepared using extrusion/spheronization method．L

)orthogonal design was used to obtain optimal formulation．The micromeritic properties and in vitro dissolution of the pellets were determined. Results Isosorbide mononitrate pellets prepared by extrusion/spheronization were all spheral and smooth．In vitro dissolution was more than 95%. Conclusion The quality of pellets is excellent. The preparation process is simple and suitable for the industrial production．

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