Protective effect of cobra venom factor on ischemia/refusion injury of cardiac transplantation in inbred rats

兰纲; 杨康; 吴蔚; 白云; 蒋彬; 李军; 熊刚

您当前的位置：

首页 >

文章列表页 >

Protective effect of cobra venom factor on ischemia/refusion injury of cardiac transplantation in inbred rats

更新时间：2026-01-09

- Protective effect of cobra venom factor on ischemia/refusion injury of cardiac transplantation in inbred rats
- Journal of Army Medical University Vol. 29, Issue 4, Pages: 357-359(2007)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R341;R392.4;R654.2
- Published：2007
- 稿件说明：
移动端阅览
兰纲,杨康,吴蔚,白云,蒋彬,李军,熊刚.CVF在大鼠移植心脏缺血再灌注损伤中的保护作用研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(04):357-359.

　LAN Gang,YANG Kang,WU Wei,BAI Yun,JIANG Bin,LI Jun,XIONG Gang.Protective effect of cobra venom factor on ischemia/refusion injury of cardiac transplantation in inbred rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(04):357-359.
兰纲,杨康,吴蔚,白云,蒋彬,李军,熊刚.CVF在大鼠移植心脏缺血再灌注损伤中的保护作用研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(04):357-359. DOI：

　LAN Gang,YANG Kang,WU Wei,BAI Yun,JIANG Bin,LI Jun,XIONG Gang.Protective effect of cobra venom factor on ischemia/refusion injury of cardiac transplantation in inbred rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(04):357-359. DOI：

摘要

目的研究中华眼镜蛇毒因子（cobra venom factor

CVF）对同种大鼠移植心脏缺血再灌注损伤的保护作用机制。方法近交系雄性B/N大鼠为供体，Lewis大鼠为受体，建立腹腔异位心脏移植模型。实验组术前给予CVF尾静脉注射，观察移植心的存活时间，并设B/N大鼠同系对照组。免疫组化法测定各组术后第1、3、5 天移植心脏的C3沉积，并观察移植心的病理变化。结果接受CVF 20 μg/kg，2 d 1次，尾静脉给药的大鼠

移植心存活时间明显延长，平均达（11.69±0.72）d，而对照组为（6.65±0.35）d（P0.01），组织内C3沉积较对照组同期明显减轻

病理损害程度减轻，优于同期对照组。结论 CVF消耗补体显著延长移植心脏存活时间，能明显减轻近交系大鼠移植心脏缺血再灌注损伤。

Abstract

Objective To study the protective effect of cobra venom factor (CVF) on ischemia/refusion injury of cardiac trasnsplantation in inbred rats. Methods Inbred male Lewis rats were used as recipients and Brown-Norway rats as donors to establish heterotopic heart transplantation model. The allograft hearts were divided into 2 groups (n=16 in each group). After the rats were infused low-dose CVF 20 g·kg

-1

·d

-2

to the CVF-treated group，the cardiac allograft survival time was observed in each group. Three rats chosen from the two groups were killed on day 1

5 in each group

and the pathologic alterations

the complement activity in serum

the deposition of C3

in tissues were compared. Results In treatment group

the survival time of the donor heart was significantly prolonged and pathologic lesion was relieved. The deposition of C3 in tissues was significantly reduced as compared with control group. Conclusion Complement depletion by CVF acts well on ameliorating cardiac ischemia/refusion injury. The survival time of cardiac allograft treated with CVF can be significantly prolonged.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of minidose CsA combined with CVF in preventing rat cardiac allograft acute rejection

C5a/C5aR signaling pathway mediates FGL2 expression in colon cancer

Protective effect of CR1-SCR1-3 protein on acute cerebral ischemia and reperfusion injury in rats

Stable expression of targeting complement inhibitor CR2-CD59 in Chinese hamster ovary cells

Related Author

杨康

兰纲

熊松柏

吴蔚

朱晓星

蒋彬

朱波

郭波

Related Institution

No data

⁰