Inchoate changes in 303 cases of Graves disease treated with <sup>131</sup>I

罗朝学; 黄定德; 刘开元; 李前伟

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Inchoate changes in 303 cases of Graves disease treated with ¹³¹I

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- Inchoate changes in 303 cases of Graves disease treated with ¹³¹I
- Journal of Army Medical University Vol. 29, Issue 7, Pages: 635-637(2007)
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  CLC： R581.105;R817.5
- Published：2007
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罗朝学,黄定德,刘开元,李前伟.131I治疗303例Graves病早期变化分析[J].陆军军医大学学报(原第三军医大学学报),2007,29(07):635-637.

　LUO Chao-xue,HUANG Ding-de,LIU Kai-yuan,LI Qian-wei.Inchoate changes in 303 cases of Graves disease treated with 131I[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(07):635-637.
罗朝学,黄定德,刘开元,李前伟.131I治疗303例Graves病早期变化分析[J].陆军军医大学学报(原第三军医大学学报),2007,29(07):635-637. DOI：

　LUO Chao-xue,HUANG Ding-de,LIU Kai-yuan,LI Qian-wei.Inchoate changes in 303 cases of Graves disease treated with 131I[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(07):635-637. DOI：

摘要

目的探讨

131

I治疗甲亢早期动态变化，评价其治疗效果。方法对303例接受

131

I治疗的甲亢患者，在治疗后6个月分别进行了随访，了解其症状、体征及用放射免疫法和免疫放射分析法测定的血清甲状腺激素浓度，并对结果进行统计学处理。结果治疗前和治疗后6个月症状、体征明显改善，各激素值较治疗时均有明显变化，且差别都有显著的统计学意义（P0.05），新增6例突眼患者。303例患者中，249例(82.2%)痊愈，21例(6.9%)好转，24例(7.9%)出现甲低，9例(3.0%)无效。总有效率为97.3%，治愈率为90.1%。结论 

131

I治疗甲亢经济、简便、安全、有效，可作为Graves病的首选治疗方法。

Abstract

Objective To explore the inchoate changes in patients with Graves disease (GD) treated with

131

I and appraise the therapeutic effect. Methods According to the thyroid size

patients’ age

thyroid

131

I intake rate and course of the disease

303 patients with GD were given individual

131

I doses. Six months later

the symptom

signs

and thyroid hormone levels of every case were compared with those recorded before. Results The symptom and the level of thyroid hormones were significantly meliorated after

131

I treatment. Six cases became goggle-eyed after treatment. Among the 303 patients

249(82.18%) fully recovered

21 (6.93%) partially remitted

24(7.92%) developed

hypothyroidism

and 9(2.97%) showed ineffective. Conclusion 

131

I treatment for GD with an individual dose can exert a satisfied therapeutic efficacy. It may as serve the first choice for GD treatment.

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Inchoate changes in 303 cases of Graves disease treated with 131I

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Inchoate changes in 303 cases of Graves disease treated with ¹³¹I