Effect of pseudo CO<sub>2</sub> pneumoperitoneum on cell adhesion capability of cultured endometrium cancer cells

陈石; 梁志清; 阎军玲

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Effect of pseudo CO₂ pneumoperitoneum on cell adhesion capability of cultured endometrium cancer cells

更新时间：2026-01-09

- Effect of pseudo CO₂ pneumoperitoneum on cell adhesion capability of cultured endometrium cancer cells
- Journal of Army Medical University Vol. 29, Issue 11, Pages: 1057-1059(2007)
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  CLC： R45;R730.23;R737.33
- Published：2007
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陈石,梁志清,阎军玲.模拟CO2气腹对人子宫内膜癌细胞黏附能力的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(11):1057-1059.

　CHEN Shi,LIANG Zhi-qing,YAN Jun-ling.Effect of pseudo CO2 pneumoperitoneum on cell adhesion capability of cultured endometrium cancer cells[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1057-1059.
陈石,梁志清,阎军玲.模拟CO2气腹对人子宫内膜癌细胞黏附能力的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(11):1057-1059. DOI：

　CHEN Shi,LIANG Zhi-qing,YAN Jun-ling.Effect of pseudo CO2 pneumoperitoneum on cell adhesion capability of cultured endometrium cancer cells[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1057-1059. DOI：

摘要

目的探讨二氧化碳（CO

）气腹环境对培养人子宫内膜癌细胞黏附能力的影响。方法体外培养人子宫内膜癌HEC-1-B细胞株，以模拟CO

气腹处理4 h，通过MTT法检测细胞生长变化和细胞黏附改变；应用免疫组织化学方法检测细胞中β

-整合素（β

-integrin）以及E-钙黏素（E-cadherin）的表达变化。结果 CO

处理4 h后，与对照组相比，HEC-1-B细胞生长曲线上移，黏附能力增强，β

-整合素与E-钙黏素的表达均减少。结论 CO

气腹有可能通过减弱子宫内膜癌细胞β

-整合素和E-钙黏素的表达导致其黏附能力增加，从而可能对肿瘤细胞的转移产生一定影响。

Abstract

Objective To investigate the effect of CO

pneumoperitoneum on the cell adhesion capability of cultured endometrium cancer cells. Methods After treated in a pneumoperitoneum model for 4 h

the changes in cell growth and adhesion of the endometrium cancer were detected by MTT. The expression of β

-integrin and E-cadherin in the cancer cells were compared with the control that were not treated with CO

by the immunohistochemical method. Results After treated with CO

for 4 h

the cell growth was enhanced and the cell adhesion capability increased as compared with the control group. At the same t

ime

the expression of β

-integrin and E-cadherin was lower in treated cells than that in untreated ones. Conclusion The adhesion capability of endometrium cancer cells in CO

pneumoperitoneum could be enhanced by the reduction of the expression of β

-integrin and E-cadherin

and thereby influences the metastasis of cancer.

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Effect of pseudo CO2 pneumoperitoneum on cell adhesion capability of cultured endometrium cancer cells

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摘要

Abstract

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Effect of pseudo CO₂ pneumoperitoneum on cell adhesion capability of cultured endometrium cancer cells