Bone microstructure changes and bone BMP-2 expression in rats at early period of diabetes

范伟; 杨妤欣; 陈隽; 蒋电明

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Bone microstructure changes and bone BMP-2 expression in rats at early period of diabetes

更新时间：2026-01-09

- Bone microstructure changes and bone BMP-2 expression in rats at early period of diabetes
- Journal of Army Medical University Vol. 29, Issue 11, Pages: 1053-1056(2007)
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  CLC： R329.26;R336;R587.102
- Published：2007
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范伟,杨妤欣,陈隽,蒋电明.糖尿病大鼠早期骨微结构改变及其BMP-2基因的表达[J].陆军军医大学学报(原第三军医大学学报),2007,29(11):1053-1056.

　FAN Wei,YANG Yu-xin,CHEN Juan,JIANG Dian-ming.Bone microstructure changes and bone BMP-2 expression in rats at early period of diabetes[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1053-1056.
范伟,杨妤欣,陈隽,蒋电明.糖尿病大鼠早期骨微结构改变及其BMP-2基因的表达[J].陆军军医大学学报(原第三军医大学学报),2007,29(11):1053-1056. DOI：

　FAN Wei,YANG Yu-xin,CHEN Juan,JIANG Dian-ming.Bone microstructure changes and bone BMP-2 expression in rats at early period of diabetes[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1053-1056. DOI：

摘要

目的观察糖尿病大鼠早期的骨密度、骨微结构改变及骨组织中BMP-2基因的表达。方法清洁级健康成年雄性Wistar大鼠30只，按照随机数字表将其分为A组(普通饲料对照组)、B组(高脂饲料＋链脲佐菌素组)和C组(普通饲料＋大剂量链脲佐菌素组)。饲养12周后，分别对各组大鼠进行骨密度、光镜、扫描电镜、骨形态计量学的观察以及BMP-2基因表达等指标的检测。结果与A组相比，B组骨微结构无明显变化（P0.05），但BMP-2基因表达增高(P0.05)，C组骨微结构明显改变(P0.05)，BMP-2基因表达降低，但差异无统计学意义（P0.05）。结论不同的糖尿病大鼠模型早期骨微结构及BMP-2基因表达情况改变不完全一致，可能与高胰岛素血症、胰岛素抵抗有一定关系。

Abstract

Objective To investigate the changes of bone density

bone microstructure

bone BMP-2 expression in rats at early period of diabetes. Methods Thirty SPF 4-month-old male Wistar rats were randomly divided into 3 groups (n=10 in each group): A (fed with common forage as normal control group)

B (fed with high-lipid forage and intraperitoneally injected with STZ to establish type 2 diabetes with insulin resistance)

C (fed with common forage and intraperitoneally injected with STZ to establish type 2 diabetes with insulin secretion defaulting). The bone histomorphology

bone histomorphometry

bone BMP-2 expression were investigated 12 weeks later. Results As compared with group A

bone microstructure was of no obvious changes and bone BMP-2 expression was higher in group B (P0.05)

and obvious bone breakage was observed in group C (P0.05). Conclusion The changes of bone microstructure and bone BMP-2 expression at the early period of diabetes are not consistent absolutely in individual rat model of diabetes. It maybe relate to hyperinsulinism and insulin resistance.

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