Changes of serum cytokines and their clinical significance in infants with cytomegalovirus infection

熊菀; 刘瑜; 陈琼; 吴扬

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Changes of serum cytokines and their clinical significance in infants with cytomegalovirus infection

更新时间：2026-01-09

- Changes of serum cytokines and their clinical significance in infants with cytomegalovirus infection
- Journal of Army Medical University Vol. 29, Issue 7, Pages: 623-625(2007)
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  CLC： R392.11;R725.1
- Published：2007
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熊菀,刘瑜,陈琼,吴扬.细胞因子水平改变在婴儿巨细胞病毒感染中的临床意义[J].陆军军医大学学报(原第三军医大学学报),2007,29(07):623-625.

　XIONG Wan,LIU Yu,CHEN Qiong,WU Yang.Changes of serum cytokines and their clinical significance in infants with cytomegalovirus infection[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(07):623-625.
熊菀,刘瑜,陈琼,吴扬.细胞因子水平改变在婴儿巨细胞病毒感染中的临床意义[J].陆军军医大学学报(原第三军医大学学报),2007,29(07):623-625. DOI：

　XIONG Wan,LIU Yu,CHEN Qiong,WU Yang.Changes of serum cytokines and their clinical significance in infants with cytomegalovirus infection[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(07):623-625. DOI：

摘要

目的了解巨细胞病毒（cytomegalovirus

CMV）感染婴儿血清TNF-α、IFN-γ、IL-4水平变化，探讨其在炎症发生过程中的作用。方法 41例CMV-IgM阳性、其他疾病组和30例CMV-IgM阳性、肝炎组作为观察对象，30例健康婴儿作为对照（对照组），ELISA法检测血清TNF-α、IFN-γ、IL-4，并分析TNF-α和ALT的相关性。结果与对照组相比，两组CMV-IgM阳性患儿TNF-α、IFN-γ、IL-4均高于对照组， IFN-γ/IL-4值显著低于对照组。肝炎组与其他疾病组相比较，TNF-α、IL-4 、IFN-γ/IL-4值的改变具有显著性差异，且肝炎组TNF-α和ALT值呈显著正相关（r=0.76，P0.01），而IFN-γ在其他疾病组和肝炎组增高均不明显。结论 CMV感染后导致患儿细胞因子分泌紊乱，表现为TNF-α水平增高，且与肝功能损害的程度密切相关；同时IFN-γ/IL-4值变化则提示由于Th

功能异常增高而导致Th

和Th

平衡失调。该研究结果对于阐明CMV感染的发病机制，改善CMV感染的防治措施提供了免疫学依据。

Abstract

Objective To investigate the changes of serum cytokines and explore their role in infants with cytomegalovirus (CMV) infection. Methods We recruited 41 positive CMV-IgM plus normal ALT infants (other disease group)

30 positive CMV-IgM plus abnormal ALT infants (hepatitis group) and 30 healthy infants (control group) in the study. The levels of tumor necrosis factor-α(TNF-α)

interferon-γ(IFN-γ) and interleukin-4 (IL-4) in serum were measured with ELISA. The association between TNF-α and ALT was analyzed. Results The

levels of TNF-α

IFN-γ

IL-4 were higher

and IFN-γ/IL-4 was significantly lower in the two CMV infection groups than the control group. Compared with other disease group

the changes of TNF-α

IL-4

and IFN-γ/IL-4 showed significance in hepatitis group. The level of TNF-α showed a positive association with ALT in hepatitis group（r=0.76，P0.01）

but IFN-γ increased slightly in both groups. Conclusion Abnormal cytokines secretion is corroborated in CMV-infected infants exhibited by the high levels of TNF-α as well as a close correlation with the inflammation extent. The changes of IFN-γ/IL-4 suggest the imbalance of Th

/Th

induced by the abnormal elevation of Th

. The conclusion will provide the immunological basis to clarify the pathogenesis of CMV infection and improve the prevention and cure measures.

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