Effects of desamethasone in pregnancy on pituitary-adrenal functions of fetus and fetal rats

陈丽; 王玉华

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Effects of desamethasone in pregnancy on pituitary-adrenal functions of fetus and fetal rats

更新时间：2026-01-09

- Effects of desamethasone in pregnancy on pituitary-adrenal functions of fetus and fetal rats
- Journal of Army Medical University Vol. 29, Issue 13, Pages: 1329-1330(2007)
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  CLC： R714.250.5;R714.51;R977.11
- Published：2007
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陈丽,王玉华.孕期应用地塞米松对胎儿及胎鼠垂体肾上腺轴功能的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(13):1329-1330.

　CHEN Li,WANG Yu-hua.Effects of desamethasone in pregnancy on pituitary-adrenal functions of fetus and fetal rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(13):1329-1330.
陈丽,王玉华.孕期应用地塞米松对胎儿及胎鼠垂体肾上腺轴功能的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(13):1329-1330. DOI：

　CHEN Li,WANG Yu-hua.Effects of desamethasone in pregnancy on pituitary-adrenal functions of fetus and fetal rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(13):1329-1330. DOI：

摘要

目的研究孕期地塞米松对子代垂体肾上腺功能的影响。方法 2003年5至11月在我院住院分娩的孕妇中，取明确诊断为肝内胆汁淤积症（ICP）且使用地塞米松治疗的孕妇24例为观察组，检测胎儿脐血皮质醇和ACTH浓度；孕鼠地塞米松注射后检测胎鼠血皮质醇和ACTH浓度及垂体ACTH免疫组织化学表达。结果 ICP孕妇使用地塞米松治疗后新生儿脐血皮质醇浓度较对照组降低及ACTH浓度升高（P0.05）；孕鼠地塞米松注射后检测胎鼠血皮质醇浓度较对照组降低（P0.05），胎鼠血ACTH浓度升高及胎鼠垂体ACTH免疫组织化学表达增强（P0.05）。结论孕期使用地塞米松对新生儿肾上腺功能存在近期影响。

Abstract

Objective To evaluate the effects of desamethasone in pregnancy on fetal pituitary-adrenal functions. Methods From May 2003 to November 2003 24 cases of intrahepatic cholestasis of pregancy (ICP) in the third trimester were treated with dexamethasone. The levels of ACTH and cortisone in the umbilical blood were detected after delivery. The pregnant Wistar rats were intramuscularly injected of dexamethasone (1 mg·kg

-1

·d

-1

) from the pregnancy day 15 for 5 days as group B

while the rats in group A received no dexamethasone as control group. The levels of ACTH and cortisone of the rat fetus as well as the ACTH in fetal pituitary gland by immunohistochemistry were examined. Results The ACTH level in the umbilical blood o

f the fetus increased and the cortisone level decreased as compared to that of the control group. Treatment with desamethasone to pregnant rats resulted in enhanced expression of ACTH

increased serum ACTH concentration

and decreased concentration of cortisol in the rat fetal pituitary gland. Conclusion Treatment with dexamethasone in pregnancy causes some impact on the adrenal gland of the newborn rats in the near future.

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Related Institution

Department of Gastroenterology， Chongqing Key Laboratory of Precise Prevention and Treatment of Digestive Malignancies， Army Medical Center of PLA/Daping Hospital of Third Military Medical University

Department of Gastrointestinal and Neonatal Surgery, Key Laboratory of Child Development and Disorders of Ministry of Education, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University

Department of Respiratory and Critical Care Medicine, First Affiliated Hospital, Army Medical University (Third Military Medical University)

Department of Pediatric Orthopedics, Children's Hospital of Nanjing Medical University

Key Laboratory of Child Development and Disorder of Ministry of Education, Chongqing International Science and Technology Cooperation Center for Development and Disorders, Chongqing Key Laboratory of Pediatrics

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