Objective     To investigate the changes and mechanisms of intestinal mucosa barrier induced by CO

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pneumoperitoneum in cirrhotic rats.      Methods     Fifty rats were randomized into four groups: normal control group (Group A)， experimental control group (Group B

Veress needle inserted only) and two pneumoperitoneum groups. In pneumoperitoneum groups the abdominal cavity of these rats were insufflated with CO

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and maintained at the pressure of 8 mmHg (Group C) and 13 mmHg (Group D) respectively for 2 h. In condition of sterilization

the portal venous blood was collected and D-lactic acid and endotoxin were measured. The structur

e of intestinal mucosa was observed.      Results     All indexes were markedly different （P0.05）between Groups A and B. All values at different time points and pneumoperitoneum pressure were markedly different in Groups C and D in comparison with  Group B （P0.05）. The endotoxin level （P0.05）

the thickness of mucous membrane（P0.05）and the height of intestinal villus (P0.01) were obviously different between Groups C and D.      Conclusion     Rats with cirrhosis are vulnerable to the damage of intestinal mucosa barrier under the condition of CO

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pneumoperitoneum.