Effect of astragalus polysaccharides and soy isoflavones on glucose metabolism in diabetic rats

廖苇萍; 石元刚

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Effect of astragalus polysaccharides and soy isoflavones on glucose metabolism in diabetic rats

更新时间：2026-01-09

- Effect of astragalus polysaccharides and soy isoflavones on glucose metabolism in diabetic rats
- Journal of Army Medical University Vol. 29, Issue 5, Pages: 416-418(2007)
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  CLC： Q519.4;R151.3;R587.1
- Published：2007
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廖苇萍,石元刚.黄芪多糖和大豆异黄酮对糖尿病大鼠糖代谢的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(05):416-418.

　LIAO Wei-ping,SHI Yuan-gang.Effect of astragalus polysaccharides and soy isoflavones on glucose metabolism in diabetic rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(05):416-418.
廖苇萍,石元刚.黄芪多糖和大豆异黄酮对糖尿病大鼠糖代谢的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(05):416-418. DOI：

　LIAO Wei-ping,SHI Yuan-gang.Effect of astragalus polysaccharides and soy isoflavones on glucose metabolism in diabetic rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(05):416-418. DOI：

摘要

目的探讨黄芪多糖和大豆异黄酮对糖尿病大鼠糖代谢的影响。方法选择健康成年SD大鼠60只，采用随机数字表法分成5组，每组12只，雌雄各半，单笼饲养，自由饮水和摄食。链尿佐菌素（streptozotocin， STZ）一次性腹腔注射建立糖尿病（diabetes mellitus，DM）模型，分别为普通饲料组、黄芪多糖高剂量组、黄芪多糖低剂量组和大豆异黄酮组干预动物喂养4、8周后，测定血糖、糖化血红蛋白、尿糖及血脂含量。结果黄芪多糖高剂量组、黄芪多糖低剂量组以及大豆异黄酮组对DM大鼠喂养8周后，血糖、糖化血红蛋白、尿糖及TC、TG、LDL、VLDL明显低于DM模型组（P0.05)，HDL明显高于DM模型组（P0.05)。结论黄芪多糖、大豆异黄酮均有降血糖和血脂功能的作用。

Abstract

Objective To explore the effect of astragalus polysaccharides (APS) and soy isoflavones (SI) on glucose metabolism in diabetic rats. Methods Healthy 60 rats were equally and randomly divided into 5 groups

normal forage group (NF)

high blood sugar model group(HBS)

APS high dose group intervention group (APS-H)

APS low dose group (APS-L)

and SI intervention group (SI). Diabetic model was inflicted by intraperitoneal injection of streptozotocin (STZ). Ordinary feed and APS high dose，low dose APS and SI interfere were respectively given for 8 weeks. Blood glucose，glycated hemoglobin，glucose and lipid levels were determined in every group. Results After APS high dose，low dose and SI were given to feed diabetic rats for 8 weeks

their blood glucose

glycated hemoglobin

glucose

LDL

VLDL and high blood glucose was significantly lower than the HBS group (P0.05)

and their HDL was significantly higher than the HBS group (P0.05). Conclusion APS and SI both exert the effect of reducing blood sugar and blood fats

and may be used to prevent diabetes and its complication.

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