Changes of TNF-alpha and malondialdehyde content in brain tissue and therapeutic effect of edaravone on rats after intracerebral hemorrhage

崔洁; 曹参祥; 郑静; 王景周

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Changes of TNF-alpha and malondialdehyde content in brain tissue and therapeutic effect of edaravone on rats after intracerebral hemorrhage

更新时间：2026-01-09

- Changes of TNF-alpha and malondialdehyde content in brain tissue and therapeutic effect of edaravone on rats after intracerebral hemorrhage
- Journal of Army Medical University Vol. 29, Issue 11, Pages: 1032-1035(2007)
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  CLC： R329.25;R743.34;R971
- Published：2007
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崔洁,曹参祥,郑静,王景周.脑出血大鼠脑组织MDA、TNF-α含量变化及其依达拉奉干预效应的研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(11):1032-1035.

　CUI Jie,CAO Can-xiang,ZHENG Jing,WANG Jing-zhou.Changes of TNF-alpha and malondialdehyde content in brain tissue and therapeutic effect of edaravone on rats after intracerebral hemorrhage[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1032-1035.
崔洁,曹参祥,郑静,王景周.脑出血大鼠脑组织MDA、TNF-α含量变化及其依达拉奉干预效应的研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(11):1032-1035. DOI：

　CUI Jie,CAO Can-xiang,ZHENG Jing,WANG Jing-zhou.Changes of TNF-alpha and malondialdehyde content in brain tissue and therapeutic effect of edaravone on rats after intracerebral hemorrhage[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1032-1035. DOI：

摘要

目的观察3-甲基-1-苯基-2-吡唑啉-5-酮（MCI-186

商品名为依达拉奉）对出血性脑组织的保护作用和可能机制。方法将96只Sprague-Dawley大鼠按随机数字表法分为假手术组、脑出血模型组、依达拉奉治疗组，每组32只。采用自体血脑内注入法制作大鼠脑出血模型，假手术组只进针不注血。依达拉奉治疗组大鼠腹腔注射依达拉奉（3 mg/kg），分别于造模前30 min及造模后1次/12 h。于6、24、72、168 h分别用Longa标准测定神经功能缺损；干、湿重法检测脑含水量；酶联免疫吸附法（ELISA)和硫代巴比妥酸法测定血肿周围组织中脑组织TNF-α和丙二醛(malondialdehyde

MDA)的含量。结果与假手术组相比，脑出血模型组大鼠神经功能缺损评分、脑含水量、TNF-α和MDA含量均显著增高（P0.05）；与脑出血模型组相比，依达拉奉治疗组大鼠神经功能缺损评分、脑含水量、TNF-α和MDA含量显著下降（P0.05）。结论依达拉奉对出血后脑组织具有保护作用，其机制可能与抑制MDA和TNF-α的活性有关。

Abstract

Objective To observe the protective effect of edaraven on brain tissue and the therapeutic mechanism in rats following intracerebral hemorrhage(ICH). Methods In this series

96 Sprague-Dawley rats were divided into three groups at random(n=32 in each group)： sham-operative group

ICH model group and edaraven therapy group. ICH model was induced by infusion of autologous whole blood into the caudate-putamen. Rats in sham-operative group were treated the same as above

but no blood injected. Rats in edaraven therapy group were treated with edaraven (3 mg/kg) by peritoneal injection 30 min before operation and once per 12 hours after operation. These rats were killed at 6

and 168 h after neurologic impairment test with Longa criteria. Brain water content was measured by dry-wet weight method. Malondialdehyde and TNF-alpha in the vicinity of the hematoma were measured by thio-barbituric acid method and ELISA respectively. Results Compared with sham operative group

neurologic impairment score

brain water content

malondialdehyde and TNF-alpha in brain tissues were obviously higher in ICH model group (P0.05). Compared with ICH model group

neurologic impairment score

brain water content

malondialdehyde and TNF-alpha in brain tissues were significantly decreased in edaraven therapy group (P0.05). Conclusion Edaraven has an evident protective effect on injured brain tissue through inhibiting malondialdehyde and TNF-alpha content in the vicinity of the hematoma.

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Department of Neurology， Second Affiliated Hospital， Army Medical University （Third Military Medical University）

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Department of Human Anatomy, College of Basic Medical Sciences, Chongqing Medical University

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